antibody

Rabbit anti tPA

MBS315815

0.2 mg

420 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Rabbit anti tPA

Tissue Plasminogen Activator (tPA)

Rabbit Antibody to Human Tissue Plasminogen Activator (tPA)

tissue plasminogen activator; Tissue-type plasminogen activator; tissue-type plasminogen activator; alteplase; reteplase; OTTHUMP00000225783; OTTHUMP00000225784; OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787; OTTHUMP00000225788; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA); plasminogen activator, tissue

PLAT; TPA; T-PA; DKFZp686I03148

TPA_HUMAN

Polyclonal

Rabbit

Human

532

Tissue Plasminogen Activator (tPA). Human tPA

Protein A chromatography

Purified, Liquid

1mg/ml (OD280nm, E^0.1% = 1.36)

Upon receipt, store at -70 degree C. Avoid multiple freeze/thaw cycles.

EIA/ELISA, Immunohistochemistry, Immunoassay Antibody Pairs, Western Blot

Immunogen: Recombinant human tPA

Buffer: 0.05M Sodium phosphate, pH 6.6 containing 0.1M Sodium chloride and 1mM EDTA. Preservative: No. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.

Polyclonal Antibodies to Platelets and Hemostasis Antigens

441174

BAA00881.1

P00750

Blood Clotting Cascade Pathway (198840); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Dissolution Of Fibrin Clot Pathway (106061); Endochondral Ossification Pathway (198812); Hemostasis Pathway (106028); Selenium Pathway (198825); Senescence And Autophagy Pathway (198780); Signaling By PDGF Pathway (106384)

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

PLAT: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration. Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism. Belongs to the peptidase S1 family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Protease; Secreted, signal peptide; Vesicle; Secreted; Motility/polarity/chemotaxis; EC 3.4.21.68; Cytoskeletal. Chromosomal Location of Human Ortholog: 8p12. Cellular Component: extracellular matrix; extracellular space; cell surface; apical part of cell; cytoplasm; extracellular region; synapse; secretory granule. Molecular Function: protein binding; serine-type endopeptidase activity. Biological Process: negative regulation of proteolysis; synaptic transmission, glutamatergic; response to peptide hormone stimulus; fibrinolysis; response to cAMP; smooth muscle cell migration; response to hypoxia; protein modification process; regulation of synaptic plasticity; platelet-derived growth factor receptor signaling pathway; blood coagulation; proteolysis; transmembrane transport; plasminogen activation. Disease: Thrombophilia, Familial, Due To Decreased Release Of Tissue Plasminogen Activator

0.2 mg

420 USD