antibody

Rabbit anti PAI-1

MBS315810

0.2 mg

420 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Rabbit anti PAI-1

Plasminogen Activator Inhibitor 1

Rabbit Antibody to Human Plasminogen Activator Inhibitor 1 (PAI-1)

plasminogen activator inhibitor 1 isoform 1; Plasminogen activator inhibitor 1; plasminogen activator inhibitor 1; serpin E1; OTTHUMP00000211478; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Endothelial plasminogen activator inhibitor; Serpin E1

SERPINE1; SERPINE1; PAI; PAI1; PAI-1; PLANH1; PAI1; PLANH1

PAI1_HUMAN

Polyclonal

Rabbit

Human

402

Plasminogen Activator Inhibitor 1. Recognizes Human PAI-1 both alone and in complex under reducing and native conditions.

Protein A chromatography

Purified, Liquid

7.0 mg/ml (OD280nm, E^0.1% = 1.36)

Store at -70 degree C. Avoid multiple freeze/thaw cycles.

EIA/ELISA, Immunohistochemistry, Western Blot

Immunogen: Recombinant human PAI-1

Buffer: 0.05M Sodium phosphate, 0.1M Sodium chloride, 1mM EDTA, pH 6.6. Preservative: No. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.

Polyclonal Antibodies to Platelets and Hemostasis Antigens

10835159

NP_000593.1

NM_000602.3

P05121

45,060 Da

Adipogenesis Pathway (198832); Blood Clotting Cascade Pathway (198840); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Circadian Clock Pathway (187173); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Direct P53 Effectors Pathway (137939); Dissolution Of Fibrin Clot Pathway (106061)

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Function: This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Subunit structure: Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Ref.14 Ref.16. Subcellular location: Secreted. Tissue specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells. Post-translational modification: Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg- -Met-370 bond. Involvement in disease: Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [. MIM:613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen. Ref.15Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions. Sequence similarities: Belongs to the serpin family.

0.2 mg

420 USD