antibody

Rabbit anti Myeloperoxidase

MBS315616

1 mL

225 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

Rabbit anti Myeloperoxidase

Myeloperoxidase

Rabbit Antibody to Human Neutrophil Myeloperoxidase

myeloperoxidase; Myeloperoxidase; myeloperoxidase; myeloperoxidase

MPO; MPO

PERM_HUMAN

Polyclonal

Rabbit

Myeloperoxidase. Neutrophil Myeloperoxidase

Ammonium sulfate precipitation and DEAE-Sephacel ion exchange chromatography. Single arc upon immunoelectrophoresis of human neutrophil granule extract. Single arc upon immunoelectrophoresis of antigen.

Purified, Liquid

1.01mg/ml. Titer: >=1:4,000 (indirect ELISA)

Short-term store at 2 to 8 degree C. Long term, store at -20 degree C. Avoid multiple freeze/thaw cycles.

EIA/ELISA, Western Blot

In Western Blot, a 1:4,000 dilution gives a strong reaction to 0.3 and 0.6 ug antigen.

Buffer: PBS. Preservative: 0.05% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Polyclonal Antibodies to Cardiac Markers

McMillen, T.S., et al., (2005), "Expression of Human Myeloperoxidase by Macrophages Promotes Atherosclerosis in Mice", Circulation, 111: 2798-2804. Castellani, L.W., et al., (2006), "Transgenic mice express human MPO -463G/A alle

4557759

NP_000241.1

NM_000250.1

P05164

83,869 Da

C-MYB Transcription Factor Network Pathway (138073); Folate Metabolism Pathway (198833); IL23-mediated Signaling Events Pathway (138000); Phagosome Pathway (153910); Phagosome Pathway (153859); Selenium Pathway (198825); Amb2 Integrin Signaling Pathway (137945)

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq]

Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Catalytic activity: Cl- + H2O2 + H+ = HClO + H2O.Cl- + H2O2 = HOCl + 2 H2O. Cofactor: Binds 1 calcium ion per monomer.Binds 1 heme B (iron-protoporphyrin IX) group covalently per monomer. Subunit structure: Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Ref.13 Ref.20. Subcellular location: Lysosome. Involvement in disease: Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [. MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis. Ref.23 Ref.24 Ref.25 Ref.26 Ref.27. Sequence similarities: Belongs to the peroxidase family. XPO subfamily.

1 mL

225 USD