antibody

Rabbit anti Rat ANP

MBS315611

0.1 mL

355 USD

polyclonal

rabbit

nonconjugated

human, rat

western blot, ELISA, immunohistochemistry, radioimmunoassay, enzyme immunoassay

Antibody

Rabbit anti Rat ANP

Atrial Natriuretic Peptide (ANP)

Rabbit Antibody to Rat Atrial Natriuretic Peptide (ANP)

atrial natriuretic peptide; Natriuretic peptides A; natriuretic peptides A; atriopeptin; cardionatrin; OTTHUMP00000002504; prepronatriodilatin; natriuretic peptide precursor A; natriuretic peptide A; CDD-ANF; PrepronatriodilatinCleaved into the following 2 chains:Cardiodilatin-related peptide; CDPAtrial natriuretic factor; ANF; Alternative name(s):; Atrial natriuretic peptide

NPPA; NPPA; ANF; ANP; PND; ATFB6; CDD-ANF; ANP; PND

ANF_HUMAN

Polyclonal

Rabbit

Rat

Atrial Natriuretic Peptide (ANP). Crossreactivity: Rat Atrial Natriuretic Peptide. Human Atrial Natriuretic Peptide. Human ACTH. Human Calcitonin. Human PTH (1-84). Vasoactive Intestinal Peptide

Neat, Lyophilized. Reconstitute with 0.1ml of 10mg/ml BSA in PBS for the equivalent of whole serum or with additional buffer for more dilute antisera.

Lyophilized: Store at 2 to 8 degree C (preferably in a dessicator). Reconstituted: Aliquot and store at -20 degree C.

EIA/ELISA, Immunohistochemistry, Radioimmunoassay, Western Blot

Immunogen: Synthetic Rat Atrial Natriuretic Polypeptide (28 amino acid sequence) covalently attached to a carrier protein.

Buffer: Not applicable. Preservative: No. Lyophilized: Yes. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.

Polyclonal Antibodies to Cardiac Markers

178638

P01160

16,708 Da

Amyloids Pathway (366238); MicroRNAs In Cardiomyocyte Hypertrophy Pathway (198784)

The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq]

Function: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilatation. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Ref.15. Subcellular location: Secreted. Post-translational modification: Cleaved by CORIN upon secretion to produce the functional hormone. Polymorphism: There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide. Involvement in disease: Defects in NPPA are the cause of atrial fibrillation familial type 6 (ATFB6) [. MIM:612201]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Ref.20. Sequence similarities: Belongs to the natriuretic peptide family. Sequence caution: The sequence CAA15955.2 differs from that shown. Reason: Erroneous initiation.

0.1 mL

355 USD