antibody

Rabbit anti Human NPR-A (a.a. 294-308)

MBS315494

0.02 mL

220 USD

polyclonal

rabbit

nonconjugated

Antibody

Rabbit anti Human NPR-A (a.a. 294-308)

Natriuretic Peptide Receptor A (NPR-A) (a.a. 294-308)

Rabbit Antibody to Human Natriuretic Peptide Receptor-A (NPR-A), (amino acids 294-308)

natriuretic peptide receptor A; Atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor 1; GC-A; ANP-A; NPR-A; ANPR-A; OTTHUMP00000035155; guanylate cyclase A; natriuretic peptide receptor A; atrionatriuretic peptide receptor A; natriuretic peptide A type receptor; atrial natriuretic peptide receptor type A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A

NPR1; NPR1; ANPa; NPRA; ANPRA; GUC2A; GUCY2A; ANPRA

ANPRA_HUMAN

Polyclonal

Rabbit

Natriuretic Peptide Receptor A (NPR-A) (a.a. 294-308). Synthetic human NPR-A peptide (294-308). Cross-reacts with rat.

Neat, Lyophilized. Reconstitute in 20ul double distilled water.

Store lyophilized product at 2 to 8 degree C. After reconstitution, store at -20 degree C. Avoid multiple freeze/thaw cycles.

Western Blot

Immunogen: Synthetic human NPR-A peptide (a.a. 294-308) poly-Lysine conjugated (LKQLKHLAYEQFNFT).

Buffer: Not applicable. Preservative: No. Lyophilized: Yes. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.

Polyclonal Antibodies to Cardiac Markers

Hirsch, J.R., et al., (2001 Aug 15), "Cellular localization, membrane distribution, and possible function of guanylyl cyclases A and 1 in collecting ducts of rat", Cardiovasc. Res., 51(3): 553-561.1

6013455

P16066

118,919 Da

Purine Metabolism Pathway (82944); Purine Metabolism Pathway (307); Vascular Smooth Muscle Contraction Pathway (96530); Vascular Smooth Muscle Contraction Pathway (96866)

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM]

Function: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. Ref.10. Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate. Subunit structure: Homodimer. Subcellular location: Membrane; Single-pass type I membrane protein. Post-translational modification: Phosphorylation of the protein kinase-like domain is required for full activation by ANP. Sequence similarities: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.Contains 1 guanylate cyclase domain.Contains 1 protein kinase domain.

0.02 mL

220 USD