Rabbit anti Hemagglutinin Peptide | MyBioSource MBS315428 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti Hemagglutinin Peptide

catalog :

MBS315428

quantity :

0.1 mg

price :

210 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS315428

products type :

Antibody

products full name :

Rabbit anti Hemagglutinin Peptide

products short name :

Hemagglutinin Peptide (HA) (YPYDVPDYA)

products name syn :

Rabbit Antibody to Hemagglutinin (HA) peptide

other names :

Hemagglutinin; Hemagglutinin

other gene names :

uniprot entry name :

HEMA_I34A0

clonality :

Polyclonal

host :

Rabbit

sequence length :

563

specificity :

Hemagglutinin (HA) peptide (YPYDVPDYA)

purity :

Immunoaffinity purified using the peptide conjugated to a solid-phase support

form :

Affinity Purified, Liquid

concentration :

1mg/ml (OD280nm, E^0.1% = 1.4)

storage stability :

Store at 2 to 8 degree C.

app notes :

ELISA: Capture: 1ug/ml. Western blot: 1.0-0.2ug/ml. Immunofluorescence: 1.0-4.0ug/ml. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such

other info1 :

Immunogen: YPYDVPDYA (Influenza hemagglutinin-HA-epitope) conjugated to KLH

other info2 :

Buffer: PBS, pH 7.2. Preservative: 0.1% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

products categories :

Polyclonal Antibodies to Proteins and Bioactive Peptides

ncbi gi num :

122886

ncbi acc num :

P03459.1

uniprot acc num :

P03459

ncbi pathways :

Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Salmonella Infection Pathway (375172); Salmonella Infection Pathway (375149)

uniprot summary :

Function: Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Subunit structure: Homotrimer of disulfide-linked HA1-HA2. Subcellular location: Virion membrane; Single-pass type I membrane protein. Potential. Host apical cell membrane; Single-pass type I membrane protein. Note: Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts. Post-translational modification: In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. One identified protease that may be involved in this process is secreted in lungs by Clara cells. By similarity.Palmitoylated. Miscellaneous: Major glycoprotein, comprises over 80% of the envelope proteins present in virus particle.The extent of infection into host organism is determined by HA. Influenza viruses bud from the apical surface of polarized epithelial cells (e.g. bronchial epithelial cells) into lumen of lungs and are therefore usually pneumotropic. The reason is that HA is cleaved by tryptase clara which is restricted to lungs. However, HAs of H5 and H7 pantropic avian viruses subtypes can be cleaved by furin and subtilisin-type enzymes, allowing the virus to grow in other organs than lungs.The influenza A genome consist of 8 RNA segments. Genetic variation of hemagglutinin and/or neuraminidase genes results in the emergence of new influenza strains. The mechanism of variation can be the result of point mutations or the result of genetic reassortment between segments of two different strains.Mutants ts1 and ts227 have a temperature-sensitive defect in the transport of the hemagglutinin from the rough endoplasmic reticulum to the Golgi apparatus. Sequence similarities: Belongs to the influenza viruses hemagglutinin family.

size1 :

0.1 mg

price1 :

210 USD

more info or order :

MyBioSource product webpage