catalog number :
MBS315419
products full name :
Sheep A' Mouse Thrombopoietin
products short name :
Thrombopoietin
products name syn :
Sheep Antibody to Mouse Thrombopoietin (TPO)
other names :
thrombopoietin; Thrombopoietin; thrombopoietin; MPL ligand; c-mpl ligand; OTTHUMP00000210502; OTTHUMP00000210503; OTTHUMP00000210504; thrombopoietin nirs variant 1; megakaryocyte stimulating factor; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; myeloproliferative leukemia virus oncogene ligand; thrombopoietin; C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand
other gene names :
THPO; THPO; ML; TPO; MGDF; MKCSF; MPLLG; MGC163194; MGDF
uniprot entry name :
TPO_HUMAN
specificity :
Thrombopoietin. Recognizes Mouse Thrombopoietin
purity :
Protein G chromatography
concentration :
1mg/ml (OD280nm, E^0.1% = 1.36)
storage stability :
Upon receipt, store at -70 degree C. Avoid multiple freeze/thaw cycles.
tested application :
EIA/ELISA, Western Blot
other info1 :
Immunogen: Recombinant mouse Thrombopoietin
other info2 :
Buffer: 0.05M Sodium phosphate, pH 6.6 containing 0.1M Sodium chloride and 1mM EDTA. Preservative: No. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.
products categories :
Polyclonal Antibodies to Cytokines and Growth Factors
ncbi acc num :
AAB33390.1
ncbi mol weight :
37,823 Da
ncbi pathways :
Formation Of Platelet Plug Pathway 106029!!Hematopoietic Cell Lineage Pathway 83078!!Hematopoietic Cell Lineage Pathway 489!!Hemostasis Pathway 106028!!Platelet Activation Pathway 106034!!Platelet Activation Triggers Pathway 106035
ncbi summary :
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Alternate splicing results in multiple transcript variants of this gene.
uniprot summary :
Function: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Subcellular location: Secreted. Domain: Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal. Involvement in disease: Defects in THPO are a cause of essential thrombocythemia (ET) [. MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Ref.10. Sequence similarities: Belongs to the EPO/TPO family.