Rabbit anti Mouse tPA | MyBioSource MBS315411 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti Mouse tPA

catalog :

MBS315411

quantity :

0.2 mg

price :

335 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS315411

products type :

Antibody

products full name :

Rabbit anti Mouse tPA

products short name :

Tissue Plasminogen Activator (tPA)

products name syn :

Rabbit Antibody to Mouse Tissue Plasminogen Activator (tPA)

other names :

tissue plasminogen activator; Tissue-type plasminogen activator; tissue-type plasminogen activator; alteplase; reteplase; OTTHUMP00000225783; OTTHUMP00000225784; OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787; OTTHUMP00000225788; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA); plasminogen activator, tissue

other gene names :

PLAT; TPA; T-PA; DKFZp686I03148

uniprot entry name :

TPA_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Mouse

sequence length :

532

specificity :

Tissue Plasminogen Activator (tPA). Recognizes mouse Tissue Plasminogen Activator (tPA). Cross-reacts with rat tPA.

purity :

Protein A chromatography

form :

Purified, Liquid

concentration :

1mg/ml (OD280nm, E^0.1% = 1.36)

storage stability :

Upon receipt, store at -70 degree C. Avoid multiple freeze/thaw cycles.

tested application :

EIA/ELISA, Western Blot

other info1 :

Immunogen: Recombinant mouse tPA

other info2 :

Buffer: 0.05M Sodium phosphate, pH 6.6 containing 0.1M Sodium chloride and 1mM EDTA. Preservative: No. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.

products categories :

Polyclonal Antibodies to Platelets and Hemostasis Antigens

ncbi gi num :

441174

ncbi acc num :

BAA00881.1

uniprot acc num :

P00750

ncbi pathways :

Blood Clotting Cascade Pathway (198840); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Dissolution Of Fibrin Clot Pathway (106061); Endochondral Ossification Pathway (198812); Hemostasis Pathway (106028); Selenium Pathway (198825); Senescence And Autophagy Pathway (198780); Signaling By PDGF Pathway (106384)

ncbi summary :

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

uniprot summary :

PLAT: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration. Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism. Belongs to the peptidase S1 family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted; Protease; Cytoskeletal; EC 3.4.21.68; Motility/polarity/chemotaxis; Vesicle. Chromosomal Location of Human Ortholog: 8p12. Cellular Component: extracellular matrix; extracellular space; cell surface; apical part of cell; cytoplasm; extracellular region; synapse; secretory granule. Molecular Function: protein binding; serine-type endopeptidase activity. Biological Process: negative regulation of proteolysis; response to peptide hormone stimulus; synaptic transmission, glutamatergic; response to cAMP; smooth muscle cell migration; protein modification process; regulation of synaptic plasticity; platelet-derived growth factor receptor signaling pathway; proteolysis; fibrinolysis; response to hypoxia; blood coagulation; transmembrane transport; plasminogen activation. Disease: Thrombophilia, Familial, Due To Decreased Release Of Tissue Plasminogen Activator

size1 :

0.2 mg

price1 :

335 USD

more info or order :

MyBioSource product webpage