Rabbit anti ACE2 C-terminal | MyBioSource MBS315251 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti ACE2 C-terminal

catalog :

MBS315251

quantity :

0.1 mg

price :

455 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS315251

products type :

Antibody

products full name :

Rabbit anti ACE2 C-terminal

products short name :

Angiotensin Converting Enzyme 2 (ACE2)(SARS Receptor) C-terminal

products name syn :

Rabbit Antibody to Human Angiotensin Converting Enzyme 2 (ACE2) (SARS Receptor), C-terminal

other names :

Angiotensin-converting enzyme 2; Angiotensin-converting enzyme 2; angiotensin-converting enzyme 2; OTTHUMP00000022963; metalloprotease MPROT15; ACE-related carboxypeptidase; angiotensin I converting enzyme 2; angiotensin-converting enzyme homolog; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH; Metalloprotease MPROT15

other gene names :

ACE2; ACE2; ACEH; DKFZp434A014

uniprot entry name :

ACE2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

specificity :

Angiotensin Converting Enzyme 2 (ACE2)(SARS Receptor) C-terminal. Reacts with Human Angiotensin Converting Enzyme 2 (ACE2, SARS Receptor) C-terminal, amino acids 788 to 805. Does not crossreact with ACE1.

purity :

Immunoaffinity purified

form :

Affinity Purified, Liquid

concentration :

1mg/ml

storage stability :

Store (up to one year) at 2 to 8 degree C.

tested application :

Western Blot

other info1 :

Immunogen: Synthetic peptide corresponding to amino acids 788 to 805 of human ACE2 (Genbank accession NP_068576).

other info2 :

Buffer: PBS. Preservative: 0.02% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

products categories :

Polyclonal Antibodies to Infectious Agents and Toxins

products references :

Donoghue, M., et al., (2000), "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9", Circ. Res., 87, 1-9. Tipnis, S.R., et al., (2000), "A human homolog of angiotensin-c

ncbi gi num :

71658783

ncbi acc num :

Q9BYF1

uniprot acc num :

Q9BYF1

ncbi mol weight :

92,463 Da

ncbi pathways :

ACE Inhibitor Pathway (198763); Protein Digestion And Absorption Pathway (172847); Protein Digestion And Absorption Pathway (171868); Renin-angiotensin System Pathway (83075); Renin-angiotensin System Pathway (486)

ncbi summary :

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq]

uniprot summary :

Function: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Ref.1 Ref.2 Ref.14. Catalytic activity: Angiotensin II + H2O = angiotensin-1-7 + L-phenylalanine. Cofactor: Binds 1 zinc ion per subunit. Ref.13Binds 1 chloride ion per subunit. Ref.13. Enzyme regulation: Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Ref.1 Ref.2 Ref.3 Ref.13. Subunit structure: Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike glycoprotein. Ref.11 Ref.14 Ref.17 Ref.20 Ref.22. Subcellular location: Processed angiotensin-converting enzyme 2: Secreted Ref.3. Cell membrane; Single-pass type I membrane protein Ref.3. Tissue specificity: Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system. Ref.1 Ref.2 Ref.3 Ref.12 Ref.16 Ref.19. Induction: Up-regulated in failing heart. Ref.1 Ref.2 Ref.3 Ref.13 Ref.15 Ref.19. Post-translational modification: N-glycosylation on Asn-90 may limit SARS infectivity. Sequence similarities: Belongs to the peptidase M2 family. Biophysicochemical propertiesKinetic parameters:KM=6.9 uM for angiotensin I Ref.13KM=2 uM for angiotensin IIKM=6.8 uM for apelin-13KM=5.5 uM for dynorphin-13pH dependence:Optimum pH is 6.5 in the presence of 1 M NaCl. Active from pH 6 to 9.

size1 :

0.1 mg

price1 :

455 USD

more info or order :

MyBioSource product webpage