antibody

MAb to Galectin-3

MBS313015

0.1 ml

645 USD

monoclonal

rat

nonconjugated

B1249M

Antibody

MAb to Galectin-3

Galectin-3

Monoclonal Antibody to Galectin-3

galectin-3; Galectin-3; galectin-3; lectin L-29; 35 kDa lectin; MAC-2 antigen; IgE-binding protein; laminin-binding protein; galactose-specific lectin 3; carbohydrate-binding protein 35; lectin, galactoside-binding, soluble, 3; 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen

LGALS3; LGALS3; L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2; MAC2

LEG3_HUMAN

Monoclonal

IgG2a, kappa

B1249M

Rat

Galectin-3. Reacts with Human and Mouse Galectin-3.

Protein G chromatography

Purified, Liquid

Store (up to one year) at 2-8 degree C.

Immunogen: Plasma membrane glycoproteins corresponding to mouse Galectin-3. Buffer: 0.1M Tris-Glycine, pH 7.4 containing 150mM Sodium chloride. Preservative: 0.05% Sodium azide

Affinity Constant: Not determined. Lyophylized: No. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Monoclonal Antibodies to Apoptosis and Signal Transduction Reagents

1. Springer, T., et al., (1981), The Journal of Biological Chemistry", 256(8): 3833-3839 2. Gasbarri, A., et al., (1999), Journal of Clinical Oncology, 17(11): 3494-3502

2385452

P17931

26,152 Da

Advanced Glycosylation Endproduct Receptor Signaling Pathway 187092!!Hedgehog Signaling Events Mediated By Gli Proteins Pathway 137912!!Immune System Pathway 106386!!Innate Immunity Signaling Pathway 106387

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.

Function: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. By similarity. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Ref.15 Ref.16 Ref.17. Subunit structure: Probably forms homo- or heterodimers. Interacts with DMBT1. By similarity. Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA. Ref.14 Ref.15. Subcellular location: Cytoplasm. Nucleus. Secreted. Note: Secreted by a non-classical secretory pathway and associates with the cell surface. Ref.5 Ref.15 Ref.17. Tissue specificity: A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Sequence similarities: Contains 1 galectin domain.

0.1 ml

645 USD