MyBioSource

antibody

MAb to Alkaline Phosphatase

MBS312841

1 mg

240 USD

monoclonal

mouse

human

MBS312841

Antibody

MAb to Alkaline Phosphatase

Alkaline Phosphatase

Alkaline Phosphatase (AP)

alkaline phosphatase; Alkaline phosphatase, tissue-nonspecific isozyme; alkaline phosphatase, tissue-nonspecific isozyme; OTTHUMP00000002971; OTTHUMP00000002972; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; Alkaline phosphatase liver/bone/kidney isozyme

AP

ALPL; ALPL; HOPS; TNAP; APTNAP; TNSALP; AP-TNAP; FLJ40094; FLJ93059; MGC161443; MGC167935; N/A

PPBT_HUMAN

Monoclonal

IgG1, kappa

B527M

Mouse

Alkaline Phosphatase (AP)

Ion exchange chromatography

Purified, Liquid

5mg/ml

Short term (up to 15 days) store at 2-8 degree C. Long term store at -20 degree C. Avoid multiple freeze/thaw cycles

Immunogen: Alkaline Phosphatase. Species Specificity: Recognizes Alkaline Phosphatase. The alkaline phosphatase (AP) maintains its enzymatic activity in the MAb-AP complex. Affinity Constant: Not determined

Buffer: PBS. Preservative: NaN3 (0.09% Sodium azide). Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Monoclonal Antibodies to Assay Detection and Miscellaneous Reagents

MAb to Alkaline Phosphatase. Monoclonal Antibody to Alkaline Phosphatase (AP)

178462

P05186

57,305 Da

Endochondral Ossification Pathway 198812!!Folate Biosynthesis Pathway 83018!!Folate Biosynthesis Pathway 404!!Metabolic Pathways 132956!!TNF-alpha/NF-kB Signaling Pathway 198884

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq]

Function: This isozyme may play a role in skeletal mineralization. Catalytic activity: A phosphate monoester + H2O = an alcohol + phosphate. Cofactor: Binds 1 magnesium ion. By similarity.Binds 2 zinc ions. Subunit structure: Homodimer. Subcellular location: Cell membrane; Lipid-anchor GPI-anchor Ref.10 Ref.11. Post-translational modification: Glycosylated. Ref.9 Ref.12. Involvement in disease: Defects in ALPL are a cause of hypophosphatasia (HOPS) [. MIM:146300]. HOPS is an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto). Ref.4 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35Defects in ALPL are a cause of hypophosphatasia childhood type (HOPSC) [. MIM:241510].Defects in ALPL are a cause of hypophosphatasia infantile type (HOPSI) [. MIM:241500]. Sequence similarities: Belongs to the alkaline phosphatase family. Sequence caution: The sequence BAD93051.1 differs from that shown. Reason: Erroneous initiation.

1 mg

240 USD