antibody

MAb to Human Alpha Fetoprotein

MBS312605

1 mg

255 USD

monoclonal

mouse

nonconjugated

B492M

ELISA, enzyme immunoassay

Antibody

MAb to Human Alpha Fetoprotein

Alpha Fetoprotein (AFP)

Monoclonal Antibody to Human Alpha Fetoprotein (AFP)

alpha-fetoprotein; Alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin

AFP; AFP; HPAFP

FETA_HUMAN

Monoclonal

IgG2a

B492M

Mouse

Human

609

Alpha Fetoprotein (AFP). Human AFP. Does not crossreact with Human Serum Albumin.

Ion exchange chromatography

Purified, Liquid

8.11 mg/mL (OD280nm)

Short term (up to 15 days) store at 2 to 8 degree C. Long term store at -20 degree C. Avoid multiple freeze/thaw cycles.

EIA/ELISA, Lateral Flow

Immunogen: Alpha Fetoprotein (AFP). Affinity Constant: Not determined

Buffer: PBS. Preservative: 0.09% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Monoclonal Antibodies for Cancer Research

178236

AAB58754.1

P02771

68,678 Da

Direct P53 Effectors Pathway (137939); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Glucocorticoid Receptor Regulatory Network Pathway (138014)

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]

Function: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Subunit structure: Dimeric and trimeric forms have been found in addition to the monomeric form. Subcellular location: Secreted. Tissue specificity: Plasma. Synthesized by the fetal liver and yolk sac. Developmental stage: Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma. Post-translational modification: Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.Sulfated. Sequence similarities: Belongs to the ALB/AFP/VDB family.Contains 3 albumin domains.

1 mg

255 USD