catalog number :
MBS312299
products full name :
MAb to FK-506
products short name :
Tacrolimus (FK-506)
products name syn :
Monoclonal Antibody to Tacrolimus (FK-506)
host :
Host: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from BALB/c mice. Source: Culture
specificity :
Tacrolimus (FK-506). Detects FK-506, a macrolide with similar but more potent immunosuppressant activity than cyclosporine. It is a 23-membered lactone produced by the bacteria Streptomyces tsukubaensis. FK-506 inhibits signal transduction and interleukin-2 transcription in CD4+ T helper lymphocytes, and is mainly used after allogenic organ transplatation to reduce organ rejection.
purity :
Euglobulin precipitation and dialysis
storage stability :
Short term store at 2 to 8 degree C. Long term aliquot and store at -20 degree C. Prepare working dilution only prior to immediate use. Avoid multiple freeze/thaw cycles.
tested application :
EIA/ELISA
other info1 :
Immunogen: FK-506 BSA conjugate. Affinity Constant: Not determined
other info2 :
Buffer: Tris buffered saline, pH 8.0. Preservative: 0.09% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
products categories :
Monoclonal Antibodies to Drugs
products references :
Letko, E., et al., (1999), "Tacrolimus (FK506)", Ann. Allergy Asthma Immunol., 83: 179-189