MAb to CD40L | MyBioSource MBS312099 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

MAb to CD40L

catalog :

MBS312099

quantity :

1 mg

price :

615 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1H4

reactivity :

human

application :

enzyme immunoassay

product information

catalog number :

MBS312099

products type :

Antibody

products full name :

MAb to CD40L

products short name :

CD40L

products name syn :

Monoclonal Antibody to Human CD40 Ligand

other names :

CD40 ligand; CD40 ligand; CD40 ligand; CD40-L; OTTHUMP00000024130; OTTHUMP00000024131; CD40 antigen ligand; T-cell antigen Gp39; T-B cell-activating molecule; TNF-related activation protein; tumor necrosis factor (ligand) superfamily member 5; CD40 ligand; T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5

other gene names :

CD40LG; CD40LG; IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L; CD40L; TNFSF5; TRAP

uniprot entry name :

CD40L_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

1H4

host :

Host: Mouse. Hybridization of Sp 2/0 myeloma cells with spleen cells from Balb/c mice. Source: Ascites

reactivity :

Human

sequence length :

261

specificity :

CD40L. Soluble human CD40L. Can be used for detection of human sCD40L in serum.

purity :

>90% pure. Protein A Sepharose chromatography. Purity is tested by electrophoresis.

form :

Purified, Liquid

concentration :

5.7mg/ml (Sigma protein assay kit)

storage stability :

Store at 2 to 8 degree C.

tested application :

EIA/ELISA, Immunoassay Antibody Pairs

other info1 :

Immunogen: Recombinant human soluble CD40 Ligand/TRAP Analog conjugates with BSA. Affinity Constant: Not determined

other info2 :

Buffer: PBS, pH 7.4. Preservative: 0.1% Sodium azide. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

products categories :

Monoclonal Antibodies to Human CDs

ncbi gi num :

4557433

ncbi acc num :

NP_000065.1

ncbi gb acc num :

NM_000074.2

uniprot acc num :

P29965

ncbi mol weight :

29,274 Da

ncbi pathways :

Adaptive Immunity Signaling Pathway (366160); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Asthma Pathway (83120); Asthma Pathway (532); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); CD40/CD40L Signaling Pathway (138061); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941)

ncbi summary :

The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq]

uniprot summary :

Function: Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Ref.10Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. Ref.10. Subunit structure: Homotrimer. Subcellular location: Cell membrane; Single-pass type II membrane protein. CD40 ligand, soluble form: Secreted. Tissue specificity: Specifically expressed on activated CD4+ T-lymphocytes. Post-translational modification: The soluble form derives from the membrane form by proteolytic processing.N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.Not O-glycosylated. Ref.9. Involvement in disease: Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [. MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. Ref.3 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21. Sequence similarities: Belongs to the tumor necrosis factor family.

size1 :

1 mg

price1 :

615 USD