catalog number :
MBS312026
products full name :
MAb to CD44
products short name :
CD44, HCAM
products name syn :
Monoclonal Antibody to CD44, HCAM, 80-95kDa
other names :
CD44; CD44 antigen (Indian blood group), isoform CRA_g; CD44 antigen; epican; Hermes antigen; OTTHUMP00000232487; OTTHUMP00000232488; OTTHUMP00000232489; OTTHUMP00000232491; OTTHUMP00000232492; OTTHUMP00000232493; OTTHUMP00000232494; OTTHUMP00000232495; OTTHUMP00000232522; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glycoprotein CD44; extracellular matrix receptor III; chondroitin sulfate proteoglycan 8; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; homing function and Indian blood group system; CD44 molecule (Indian blood group)
other gene names :
CD44; CD44; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; MGC10468
uniprot entry name :
O95370_HUMAN
host :
Mouse. Hybridization of NS1 myeloma cells with spleen cells from Balb/c mice.
specificity :
CD44, HCAM. The antibody recognizes a 80-95kDa transmembrane molecule with extensive glycosylations (O-linked and N-linked). Leucocytes and erythrocytes are positive. The antibody can immunoprecipitate 3H-Hyaluronate binding activity. This antibody does
form :
Purified, Lyophilized. Reconstitute with 1ml distilled water.
storage stability :
Store lyophilized product at 2 to 8 degree C. After reconstitution, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles. The addition of 0.1% (w/v) sodium azide is recommended for storage up to one month at 2 to 8 degree C.
app notes :
Fluorescence microscopy or flow cytometry: 2ug/5x105 cells/test. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excl
other info1 :
Immunogen: LAZ 221 ALL. Affinity Constant: Not determined
other info2 :
Buffer: Lyophilized from PBS containing 1mg/ml BSA. Preservative: No. Lyophilized: Yes. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.
products categories :
Monoclonal Antibodies to Human CDs
products references :
Pesando, J.M, et al., (1986), "Antibody-induced antigenic modulation is antigen dependent : Characterization of 22 proteins on a malignant human B cell line". J. Immunol., 137, 3689-3695. Stamenkovic, I., et al., (1989), "A lymp
ncbi mol weight :
15,635 Da
ncbi pathways :
Cytokine Signaling In Immune System Pathway 366171!!ECM-receptor Interaction Pathway 83068!!ECM-receptor Interaction Pathway 479!!Hematopoietic Cell Lineage Pathway 83078!!Hematopoietic Cell Lineage Pathway 489!!Immune System Pathway 106386!!Interferon Signaling Pathway 187103!!Interferon Gamma Signaling Pathway 187106!!Osteopontin-mediated Events Pathway 137960!!Paxillin-independent Events Mediated By A4b1 And A4b7 Pathway 137971
ncbi summary :
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq]