MAb to PAI-1 | MyBioSource MBS311800 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MAb to PAI-1

catalog :

MBS311800

quantity :

0.2 mg

price :

480 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[3E529]

reactivity :

human

application :

ELISA, other

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS311800

products type :

Antibody

products full name :

MAb to PAI-1

products short name :

[Plasminogen Activator Inhibitor 1]

products name syn :

[Monoclonal Antibody to Human Plasminogen Activator Inhibitor 1 (PAI-1)]

other names :

[plasminogen activator inhibitor 1 isoform 1; Plasminogen activator inhibitor 1; plasminogen activator inhibitor 1; serpin E1; OTTHUMP00000211478; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Endothelial plasminogen activator inhibitor; Serpin E1]

other gene names :

[SERPINE1; SERPINE1; PAI; PAI1; PAI-1; PLANH1; PAI1; PLANH1]

uniprot entry name :

PAI1_HUMAN

clonality :

Monoclonal

isotype :

IgG

clone :

[3E529]

host :

Mouse

sequence length :

402

specificity :

Recognizes both free and complexed forms of Human PAI-1.

purity :

>98% pure (SDS-PAGE). Protein A chromatography

form :

Purified, Liquid

concentration :

3.4 mg/ml (OD280nm, E 0.1% = 1.36)

storage stability :

Store at -70°C. Avoid multiple freeze/thaw cycles.

tested application :

Suitable for use in ELISA. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded .

other info1 :

Source: Asctites. Immunogen: Recombinant human PAI. Affinity Constant: Not determined

other info2 :

Buffer: 0.05M Sodium phosphate, 0.1M Sodium chloride, 1mM EDTA, pH 6.6. Preservative: None. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.

products categories :

Monoclonal Antibodies to Platelets and Hemostasis Antigens

ncbi gi num :

10835159

ncbi acc num :

NP_000593.1

ncbi gb acc num :

NM_000602.3

uniprot acc num :

P05121

ncbi pathways :

Adipogenesis Pathway (198832); Blood Clotting Cascade Pathway (198840); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Circadian Clock Pathway (187173); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Direct P53 Effectors Pathway (137939); Dissolution Of Fibrin Clot Pathway (106061)

ncbi summary :

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

uniprot summary :

Function: This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Subunit structure: Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Ref.14 Ref.16. Subcellular location: Secreted. Tissue specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells. Post-translational modification: Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg- -Met-370 bond. Involvement in disease: Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [. MIM:613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen. Ref.15Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions. Sequence similarities: Belongs to the serpin family.

size1 :

0.2 mg

price1 :

480 USD

more info or order :

MyBioSource product webpage