MAb to CD36 | MyBioSource MBS311750 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MAb to CD36

catalog :

MBS311750

quantity :

0.2 mg

price :

325 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

289-10930

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS311750

products type :

Antibody

products full name :

MAb to CD36

products short name :

CD36

products name syn :

Monoclonal Antibody to Human CD36

other names :

CD36; Platelet glycoprotein 4; platelet glycoprotein 4; GPIIIB; PAS IV; PAS-4 protein; glycoprotein IIIb; OTTHUMP00000207872; OTTHUMP00000207874; OTTHUMP00000207879; OTTHUMP00000207881; OTTHUMP00000207938; OTTHUMP00000229733; cluster determinant 36; fatty acid translocase; platelet glycoprotein IV; scavenger receptor class B, member 3; leukocyte differentiation antigen CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor); Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor

other gene names :

CD36; CD36; FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; GP3B; GP4

uniprot entry name :

CD36_HUMAN

clonality :

Monoclonal

isotype :

IgM

clone :

289-10930 (SM?)

host :

Host: Mouse. Source: Tissue Culture

reactivity :

Human

sequence length :

472

specificity :

CD36. Human CD36

purity :

>90% pure (SDS-PAGE). S-300 Sepharose size exclusion chromatography.

form :

Purified, Liquid

concentration :

1.0mg/ml (OD280nm, E^0.1% = 1.2)

storage stability :

Short-term (up to 7 days) store at 2 to 8 degree C. Long term, aliquot and store at <-40 degree C. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used. Avoid repeated freeze/th

other info1 :

Immunogen: Human tonsil cells and PBM. Affinity Constant: Not determined

other info2 :

Buffer: 10mM Phosphate, pH 7.4 containing 150mM Sodium chloride. Preservative: 0.1% Sodium Azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

products categories :

Monoclonal Antibodies to Human CDs

products references :

Hogg, N.H. et al (1984) Immunology 53:753. Linch, D.C et al (1984) Blood 63:566

ncbi gi num :

525233

ncbi acc num :

CAA83662.1

uniprot acc num :

P16671

ncbi mol weight :

53,053 Da

ncbi pathways :

Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!Collagen Adhesion Via Gp IV Pathway 106032!!Diabetes Pathways 105902!!ECM-receptor Interaction Pathway 83068!!ECM-receptor Interaction Pathway 479!!Fat Digestion And Absorption Pathway 194385!!Fat Digestion And Absorption Pathway 194324!!Formation Of Platelet Plug Pathway 106029!!Hematopoietic Cell Lineage Pathway 83078

ncbi summary :

The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

uniprot summary :

Function: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic efects. Ref.20 Ref.22. Subunit structure: Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Ref.12. Subcellular location: Membrane; Multi-pass membrane protein. Post-translational modification: N-glycosylated and O-glycosylated with a ratio of 2:1. Ref.8 Ref.14 Ref.15 Ref.16. Polymorphism: Genetic variation in CD36 influences the severity and outcome of malaria infection. Involvement in disease: Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[. MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Ref.17 Ref.21Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [. MIM:610938]. Ref.23. Sequence similarities: Belongs to the CD36 family. Sequence caution: The sequence AAM14636.2 differs from that shown. Reason: Frameshift at position 53.

size :

0.2 mg

price :

325 USD

more info or order :

MyBioSource product webpage