antibody

MAb to Alpha Fetoprotein (AFP)

MBS311665

1 mg

300 USD

monoclonal

mouse

nonconjugated

ELISA, immunohistochemistry, other

Antibody

MAb to Alpha Fetoprotein (AFP)

[Alpha Fetoprotein (AFP)]

[alpha-fetoprotein; Alpha-fetoprotein; alpha-fetoprotein; alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin]

[AFP; AFP; FETA; HPAFP; AFP; HPAFP]

FETA_HUMAN

Monoclonal

IgG2b, kappa

Mouse

Human

609

Human Alpha Fetoprotein

Protein A chromatography. Product is 0.2um filtered.

Purified, Liquid

5.0mg/ml (OD280nm, E^0.1% = 1.4)

Short term (up to 7 days) store at 2 to 8°C. Long term, aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

Suitable for use in Immunohistochemistry and ELISA. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Source: Ascites. Immunogen: AFP prepared from human placenta

Buffer: 10mM Phosphate, pH 7.2 containing 150mM Sodium chloride. Preservative: 0.1% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Monoclonal Antibodies for Cancer Research

MAb to AFP; Monoclonal Antibody to Human Alpha Fetoprotein (AFP)

178236

AAB58754.1

P02771

Direct P53 Effectors Pathway (137939); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Glucocorticoid Receptor Regulatory Network Pathway (138014)

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq]

Function: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Subunit structure: Dimeric and trimeric forms have been found in addition to the monomeric form. Subcellular location: Secreted. Tissue specificity: Plasma. Synthesized by the fetal liver and yolk sac. Developmental stage: Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma. Post-translational modification: Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.Sulfated. Sequence similarities: Belongs to the ALB/AFP/VDB family.Contains 3 albumin domains.

1 mg

300 USD