antibody

MAb to PSA, Free

MBS311577

1 mg

550 USD

monoclonal

mouse

nonconjugated

[8A6]

ELISA, enzyme immunoassay

Antibody

MAb to PSA, Free

[Prostate Specific Antigen (PSA) Free]

[Monoclonal Antibody to Prostate Specific Antigen (PSA), Free]

[prostate-specific antigen isoform 1 preproprotein; Prostate-specific antigen; prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen; kallikrein-related peptidase 3; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase]

[KLK3; KLK3; APS; PSA; hK3; KLK2A1; APS]

KLK3_HUMAN

m

IgG2a

[8A6]

mouse

261

Prostate Specific Antigen (PSA) Free. Specific for free PSA, epitope 1. No cross-reactivity with human kallikrein 2.

>90% pure (SDS-PAGE). Protein A chromatography

Purified, Liquid

5.9 mg/ml (OD280nm, E^0.1% = 1.4)

Store at 2 to 8 degree C.

EIA/ELISA, Immunoassay Antibody Pairs

Detection of free PSA antigen in two-site immunoassay. May be used in lateral flow. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not

Immunogen: Human PSA antigen purified from seminal plasma. Affinity Constant: Not determined

Buffer: PBS, pH 7.4. Preservative: 0.1% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Monoclonal Antibodies for Cancer Research

4502173

NP_001639.1

NM_001648.2

P07288

28,741 Da

Coregulation Of Androgen Receptor Activity Pathway (138085); Diabetes Pathways (105902); FOXA1 Transcription Factor Network Pathway (137979); Pathways In Cancer (83105); Prostate Cancer Pathway (83111); Prostate Cancer Pathway (523); Regulation Of Androgen Receptor Activity Pathway (138027); Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq]

Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Catalytic activity: Preferential cleavage: -Tyr- -Xaa-. Enzyme regulation: Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Ref.18. Subcellular location: Secreted. Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain. Sequence caution: The sequence AAD14185.1 differs from that shown. Reason: Erroneous initiation.

1 mg

550 USD