antibody

MAb to AFP Receptor

MBS311570

1 mg

450 USD

monoclonal

mouse

nonconjugated

5.00E+01

western blot, immunocytochemistry

Antibody

MAb to AFP Receptor

Alpha Fetoprotein (AFP) Receptor

Monoclonal Antibody to Human Alpha-Fetoprotein receptor (AFPr)

alpha-fetoprotein; Alpha-fetoprotein; alpha-fetoprotein; alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin

AFP; AFP; FETA; HPAFP; AFP; HPAFP

FETA_HUMAN

Monoclonal

IgG2a

5.00E+01

Host: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from Balb/c mice. Source: Ascites

609

Alpha Fetoprotein (AFP) Receptor. Reacts with determinant of human alpha-fetoprotein receptor. Does not react with human IgG.

>90% pure. Protein A Sepharose chromatography. Purity is tested by electrophoresis.

Purified, Liquid

3.8mg/ml (OD280nm, E^0.1% = 1.4)

Store at 2 to 8 degree C.

Immunocytochemistry, Western Blot

Cytochemistry, blocking of AFP/AFP-R and Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Immunogen: Purified human alpha-fetoprotein receptor. Affinity Constant: Not determined.

Buffer: PBS, pH 7.4. Preservative: 0.1% Sodium Azide. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Monoclonal Antibodies for Cancer Research

178236

AAB58754.1

P02771

68,678 Da

Direct P53 Effectors Pathway (137939); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Glucocorticoid Receptor Regulatory Network Pathway (138014)

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq]

Function: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Subunit structure: Dimeric and trimeric forms have been found in addition to the monomeric form. Subcellular location: Secreted. Tissue specificity: Plasma. Synthesized by the fetal liver and yolk sac. Developmental stage: Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma. Post-translational modification: Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.Sulfated. Sequence similarities: Belongs to the ALB/AFP/VDB family.Contains 3 albumin domains.

1 mg

450 USD