MyBioSource

antibody

MAb to CRP

MBS311565

1 mg

410 USD

monoclonal

mouse

human

western blot

MBS311565

Antibody

MAb to CRP

C Reactive Protein (CRP)

Monoclonal Antibody to Human C-Reactive Protein (CRP)

C-reactive protein; C-reactive protein; C-reactive protein; pentraxin 1; OTTHUMP00000033307; C-reactive protein, pentraxin-related; N/A

CRP; CRP; PTX1; MGC88244; MGC149895; PTX1

CRP_HUMAN

Monoclonal

IgG2b

C1

Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from Balb/c mice.

224

C Reactive Protein (CRP). Human CRP. Does not recognize the antigen in the absence of Ca^2+ (samples containing EDTA).

>90% pure. Protein A Sepharose chromatography. Purity is tested by electrophoresis

Purified, Liquid

7.9mg/ml (Sigma protein assay kit). Titer: >10^-6 (ELISA)

Store at 2 to 8 degree C.

Western Blot

CRP immunoassay, immunoaffinity purification and Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be exclud

Immunogen: Human CRP. Affinity Constant: Not determined

Buffer: PBS, pH 7.4. Preservative: 0.1% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Monoclonal Antibodies to Proteins and Bioactive Peptides

117486

P02741.1

P02741

25,039 Da

Classical Antibody-mediated Complement Activation Pathway 106409!!Complement Cascade Pathway 106405!!Creation Of C4 And C2 Activators Pathway 106407!!IL6-mediated Signaling Events Pathway 137932!!Immune System Pathway 106386!!Initial Triggering Of Complement Pathway 106406!!Innate Immunity Signaling Pathway 106387!!Selenium Pathway 198825

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq]

Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Cofactor: Binds 2 calcium ions per subunit. Subunit structure: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Subcellular location: Secreted. Tissue specificity: Found in plasma. Induction: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6//interleukin-6. Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium. Sequence similarities: Belongs to the pentaxin family.Contains 1 pentaxin domain. Mass spectrometry: Molecular mass is 23028 Da from positions 19 - 224. Determined by MALDI. Ref.15Molecular mass is 22930 Da from positions 19 - 223. Determined by MALDI. Ref.15

1 mg

410 USD