antibody

MAb to Osteonectin

MBS311257

0.1 mg

235 USD

monoclonal

mouse

nonconjugated

N50

western blot, ELISA, radioimmunoassay, enzyme immunoassay

Antibody

MAb to Osteonectin

Osteonectin, human (SPARC), (BM-40)

Monoclonal Antibody to Osteonectin (SPARC), (BM-40)

osteonectin; SPARC; SPARC; BM-40; osteonectin; OTTHUMP00000160617; cysteine-rich protein; basement-membrane protein 40; secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin); Basement-membrane protein 40; BM-40; Osteonectin; ON; Secreted protein acidic and rich in cysteine

SPARC; SPARC; ON; ON

SPRC_HUMAN

Monoclonal

IgG1

N50

Mouse

Human

Osteonectin, human (SPARC), (BM-40). Recognizes Human and bovine bone osteonectin, human platelet osteonectin. SPARC produced by various cells grown in culture. Cross-reacts with Rat Osteonectin.

>=95% pure (SDS-PAGE). Ammonium sulfate precipitation, ion-exchange chromatography and gel filtration

Purified, Liquid

10.8mg/ml (OD280nm, E^1% = 14)

Upon receipt, store at -20 degree C. Avoid multiple freeze/thaw cycles.

EIA/ELISA, Immunohistochemistry - Paraffin, Radioimmunoassay, Western Blot

Immunogen: Crude bone extract containing native osteonectin. Affinity Constant: 5 x 10^-9 M

Buffer: 50% glycerol/H2O (vol/vol). Preservative: No. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.

Monoclonal Antibodies for Bone and Calcium Metabolism

338325

P09486

34,632 Da

Formation Of Platelet Plug Pathway (106029); Hemostasis Pathway (106028); Platelet Activation Pathway (106034); Platelet Degranulation Pathway (106050); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048); Senescence And Autophagy Pathway (198780); TGF-beta Receptor Signaling Pathway (198774)

Secreted protein acidic and rich in cysteine/osteonectin/BM40, or SPARC, is a matrix-associated protein that elicits changes in cell shape, inhibits cell-cycle progression, and influences the synthesis of extracellular matrix (ECM) (Bradshaw et al., 2003 [PubMed 12721366]).[supplied by OMIM]

Function: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca2+ with a low affinity and an EF-hand loop that binds a Ca2+ ion with a high affinity. Subcellular location: Secreted extracellular space extracellular matrix basement membrane. Note: In or around the basement membrane. Ref.10 Ref.11 Ref.12 Ref.13. Developmental stage: Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair. Sequence similarities: Belongs to the SPARC family.Contains 1 EF-hand domain.Contains 1 follistatin-like domain.Contains 1 Kazal-like domain. Sequence caution: The sequence AAA60993.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.

0.1 mg

235 USD