MAb to Transferrin, N-terminal | MyBioSource MBS311187 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

MAb to Transferrin, N-terminal

catalog :

MBS311187

quantity :

1 mg

price :

400 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2A2

reactivity :

human

application :

enzyme immunoassay

product information

catalog number :

MBS311187

products type :

Antibody

products full name :

MAb to Transferrin, N-terminal

products short name :

Transferrin, N-terminal

products name syn :

Monoclonal Antibody to Transferrin, N-Terminal

other names :

serotransferrin; Serotransferrin; serotransferrin; siderophilin; OTTHUMP00000197155; beta-1 metal-binding globulin; transferrin; Beta-1 metal-binding globulin; Siderophilin

other gene names :

TF; TF; PRO1557; PRO2086; DKFZp781D0156

uniprot entry name :

TRFE_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

2A2

host :

Host: Mouse. Hybridization of SP2/0 myeloma cells with spleen cells from Balb/c mice. Source: Ascites

sequence length :

698

specificity :

Transferrin, N-terminal. Transferrin, human. Reacts with N-terminal domain of human transferrin. Does not cross-react with mouse, rabbit, bovine transferrin and with human lactoferrin. At 10-6M this clone inhibits proliferation of Con-A stimulated perip

purity :

>=95% pure (SDS-PAGE). Protein G chromatography

form :

Purified, Liquid

concentration :

4.6mg/ml (OD280nm, E^0.1% = 1.4)

storage stability :

Store at 2 to 8 degree C.

tested application :

EIA/ELISA, Immunohistochemistry - Paraffin

app notes :

For use in indirect immunofluorescence on fixed, paraffin embedded human brain tissue. Also for use in ELISA. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use

other info1 :

Immunogen: Purified transferrin from pooled human plasma. Affinity Constant: 2.85 x 10^-11 M

other info2 :

Buffer: PBS, pH 7.4. Preservative: 0.1% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

products categories :

Monoclonal Antibodies to Proteins and Bioactive Peptides

ncbi gi num :

4557871

ncbi acc num :

NP_001054.1

ncbi gb acc num :

NM_001063.3

uniprot acc num :

P02787

ncbi mol weight :

77,064 Da

ncbi pathways :

EPHB Forward Signaling Pathway (138047); Formation Of Platelet Plug Pathway (106029); HIF-1-alpha Transcription Factor Network Pathway (138045); Hemostasis Pathway (106028); Iron Uptake And Transport Pathway (187191); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Platelet Activation Pathway (106034); Platelet Degranulation Pathway (106050); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048)

ncbi summary :

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq]

uniprot summary :

Function: Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Subunit structure: Monomer. Subcellular location: Secreted. Tissue specificity: Expressed by the liver and secreted in plasma. Polymorphism: Different polymorphic variants of transferrin are known. The sequence shown is the predominant electrophoretic variant (C1 or TF*C1). Involvement in disease: Defects in TF are the cause of atransferrinemia (ATRAF) [. MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Ref.4 Ref.39. Sequence similarities: Belongs to the transferrin family.Contains 2 transferrin-like domains. Sequence caution: The sequence AAF22007.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

size1 :

1 mg

price1 :

400 USD