MAb to Troponin I-Cardiac | MyBioSource MBS311151 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

MAb to Troponin I-Cardiac

catalog :

MBS311151

quantity :

1 mg

price :

495 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

280

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS311151

products type :

Antibody

products full name :

MAb to Troponin I-Cardiac

products short name :

Troponin I-Cardiac (23-29 Region)

products name syn :

Monoclonal Antibody to Human Cardiac Troponin I (cTnI)

other names :

troponin I, cardiac muscle; Troponin I, cardiac muscle; troponin I, cardiac muscle; troponin I type 3 (cardiac); Cardiac troponin I

other gene names :

TNNI3; TNNI3; CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; MGC116817; TNNC1

uniprot entry name :

TNNI3_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

280 (4C2)

host :

Mouse. Hybridization of SP2/0 myeloma cells with spleen cells from Balb/c mice.

sequence length :

210

specificity :

Troponin I-Cardiac (23-29 Region). Reacts equally with free cardiac troponin I (cTnI) and cTnI forming complexes with other troponin components. Not affected by heparin, phosphorylation, oxidation and troponin complex formation. Recognizes an epitope lo

purity :

>90% pure (SDS-PAGE). Protein A chromatography

form :

Purified, Liquid

concentration :

9.4mg/ml (Sigma protein assay kit)

storage stability :

Store at 2 to 8 degree C.

tested application :

EIA/ELISA, LF, Western Blot

other info1 :

Immunogen: Native troponin complex

other info2 :

Buffer: PBS, pH 7.4. Preservative: 0.1% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

products categories :

Monoclonal Antibodies to Cardiac Markers

ncbi gi num :

151101270

ncbi acc num :

NP_000354.4

ncbi gb acc num :

NM_000363.4

uniprot acc num :

P19429

ncbi mol weight :

24,008 Da

ncbi pathways :

Cardiac Muscle Contraction Pathway 93344!!Cardiac Muscle Contraction Pathway 93992!!Dilated Cardiomyopathy Pathway 121494!!Dilated Cardiomyopathy Pathway 121285!!Hypertrophic Cardiomyopathy (HCM) Pathway 114229!!Hypertrophic Cardiomyopathy (HCM) Pathway 106591!!Muscle Contraction Pathway 106261!!Striated Muscle Contraction Pathway 106262!!Striated Muscle Contraction Pathway 198903

ncbi summary :

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq]

uniprot summary :

Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Subunit structure: Binds to actin and tropomyosin. Interacts with TRIM63. Ref.7. Involvement in disease: Defects in TNNI3 are the cause of cardiomyopathy familial hypertrophic type 7 (CMH7) [. MIM:613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Ref.10 Ref.11 Ref.13 Ref.15 Ref.17Defects in TNNI3 are the cause of cardiomyopathy familial restrictive type 1 (RCM1) [. MIM:115210]. RCM1 is an heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [. MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Ref.16Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [. MIM:613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Sequence similarities: Belongs to the troponin I family.

size :

1 mg

price :

495 USD