antibody

MAb to Transferrin

MBS311097

1 mg

465 USD

monoclonal

mouse

nonconjugated

[12A6]

ELISA, enzyme immunoassay

Antibody

MAb to Transferrin

[Transferrin]

[Monoclonal Antibody to Human Transferrin]

[serotransferrin; Serotransferrin; serotransferrin; siderophilin; OTTHUMP00000197155; beta-1 metal-binding globulin; transferrin; Beta-1 metal-binding globulin; Siderophilin]

[TF; TF; PRO1557; PRO2086; DKFZp781D0156]

TRFE_HUMAN

m

IgG1

[12A6]

mouse

Human

698

Transferrin. Human Transferrin

>90% pure. Protein A Sepharose chromatography. Purity is tested by electrophoresis.

Purified, Liquid

3.6 mg/ml (Sigma protein assay kit)

Store at 2 to 8 degree C.

EIA/ELISA, Immunoassay Antibody Pairs

Capture: MBS311238; Detection: MBS311097

Immunogen: Placental transferrin receptor or transferrin. Affinity Constant: Not determined

Buffer: PBS, pH 7.4. Preservative: 0.1% Sodium Azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Monoclonal Antibodies to Proteins and Bioactive Peptides

4557871

NP_001054.1

NM_001063.3

P02787

77,064 Da

EPHB Forward Signaling Pathway (138047); Formation Of Platelet Plug Pathway (106029); HIF-1-alpha Transcription Factor Network Pathway (138045); Hemostasis Pathway (106028); Iron Uptake And Transport Pathway (187191); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Platelet Activation Pathway (106034); Platelet Degranulation Pathway (106050); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048)

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq]

TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 3q22.1. Cellular Component: extracellular space; cell surface; early endosome; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; endocytic vesicle; perinuclear region of cytoplasm; apical plasma membrane; late endosome; basal plasma membrane; endosome membrane; vesicle. Molecular Function: protein binding; ferric iron binding; ubiquitin protein ligase binding. Biological Process: platelet activation; retinal homeostasis; platelet degranulation; cellular iron ion homeostasis; transferrin transport; blood coagulation; transmembrane transport. Disease: Atransferrinemia

1 mg

465 USD