antibody

MAb to Troponin T-Cardiac

MBS311087

1 mg

495 USD

monoclonal

mouse

nonconjugated

1C11

western blot, ELISA, enzyme immunoassay

Antibody

MAb to Troponin T-Cardiac

Troponin T-Cardiac (95-181 Region)

Monoclonal Antibody to Human Cardiac Troponin T (cTnT)

troponin T, cardiac muscle; Troponin T, cardiac muscle; troponin T, cardiac muscle; cTnT; tnTc; Troponin T cardiac; cardiac troponin T2; troponin T2, cardiac; cardiac muscle troponin T; troponin T type 2 (cardiac); Cardiac muscle troponin T

Tnnt2; Tnnt2; Ctt; CTTG; Tnnt3; RATCTTG

TNNT2_RAT

Monoclonal

IgG1

1C11

Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from BALB/c mice

Troponin T-Cardiac (95-181 Region). Human cardiac troponin T. Recognizes an epitope located between amino acid residues 95 and 181 of cTnT. No cross-reactivity with human skeletal Troponin T. Reactive with cTnT from human, mouse, rat and dog.

>90% pure. Protein A chromatography

Purified, Liquid

12.3mg/ml (Sigma protein assay)

Store at 2 to 8 degree C.

EIA/ELISA, Immunoassay Antibody Pairs, Western Blot

Immunogen: Free Human Cardiac Troponin T. Affinity Constant: Not determined

Buffer: PBS, pH 7.4. Preservative: 0.1% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Monoclonal Antibodies to Cardiac Markers

FEBS, (1993), Volume 315, 1, 25-283

6981666

NP_036808.1

NM_012676.1

P50753

35,730 Da

Cardiac Muscle Contraction Pathway (93346); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121476); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114014); Hypertrophic Cardiomyopathy (HCM) Pathway (106591); Muscle Contraction Pathway (368482); Striated Muscle Contraction Pathway (368483); Striated Muscle Contraction Pathway (198436)

tropomyosin-binding subunit of troponin; confers calcium-sensitivy to actinomysin ATPase activity in striated muscle [RGD]

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Motor. Cellular Component: sarcomere; troponin complex; myofibril; cytoplasm; striated muscle thin filament. Molecular Function: protein binding, bridging; troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding. Biological Process: actin crosslink formation; protein heterooligomerization; atrial cardiac muscle morphogenesis; regulation of muscle contraction; metabolic process; heart development; regulation of muscle filament sliding speed; sarcomere organization; regulation of heart contraction; muscle filament sliding; muscle contraction; positive regulation of ATPase activity; ventricular cardiac muscle morphogenesis; response to calcium ion; negative regulation of ATPase activity; cardiac muscle contraction

1 mg

495 USD