antibody

MAb to Human Alpha Fetoprotein

MBS310966

1 mg

430 USD

monoclonal

mouse

nonconjugated

[1305]

Antibody

MAb to Human Alpha Fetoprotein

[Alpha Fetoprotein (AFP)]

[Monoclonal Antibody to Human Alpha Fetoprotein (AFP)]

[alpha-fetoprotein; Alpha-fetoprotein; alpha-fetoprotein; alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin]

[AFP; AFP; FETA; HPAFP; AFP; HPAFP]

FETA_HUMAN

m

IgG1

[1305]

mouse

609

Alpha Fetoprotein (AFP). No cross-reactivity with Human Albumin, CEA, Ferritin, hCG, PSA.

Prosep A purified

Purified, Liquid

3.02 mg/ml (OD280nm, E^1% = 14)

Short-term (up to 6 months) store at 2 to 8 degree C. Long term, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.

Immunoassay Antibody Pairs

For enzyme conjugation, radio labeling or solid phase immobilization. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. Capture: MBS310966; Detection: MBS310949

Immunogen: Purified AFP from Cord Blood. Affinity Constant: 5 x 10^9

Buffer: PBS, pH 7.4 +/- 0.1. Preservative: 0.1% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Monoclonal Antibodies for Cancer Research

178236

AAB58754.1

P02771

68,678 Da

Direct P53 Effectors Pathway (137939); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Glucocorticoid Receptor Regulatory Network Pathway (138014)

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq]

AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 4q13.3. Cellular Component: extracellular space; cytoplasm. Molecular Function: metal ion binding. Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle. Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of

1 mg

430 USD