MAb to Apolipoprotein AI | MyBioSource MBS310954 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MAb to Apolipoprotein AI

catalog :

MBS310954

quantity :

1 mg

price :

370 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1402

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS310954

products type :

Antibody

products full name :

MAb to Apolipoprotein AI

products short name :

Apolipoprotein AI (Apo AI)

products name syn :

Monoclonal Antibody to Human Apolipoprotein AI (Apo AI)

other names :

apolipoprotein AI; Apolipoprotein A-I; apolipoprotein A-I; apo-AI; apoA-I; OTTHUMP00000043268; OTTHUMP00000069346; OTTHUMP00000069347; OTTHUMP00000069348; apolipoprotein A-I; Apolipoprotein A1

other gene names :

APOA1; APOA1; MGC117399

uniprot entry name :

APOA1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

1402

host :

Host: Mouse. Hybridization of P3X63-Ag8.653 myeloma cells with spleen cells from BALB/c mice. Source: Ascites

sequence length :

267

specificity :

Apolipoprotein AI (Apo AI). Does not cross react with Apo A-II or Apo B.

purity :

DEAE-chromatography

form :

Purified, Liquid

concentration :

6.45mg/ml (OD280nm, E^1% = 14)

storage stability :

Short-term (up to 6 months) store at 2 to 8 degree C. Long term, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.

other info1 :

Immunogen: Purified human plasma Apo A-I. Affinity Constant: 1 x 10^9

other info2 :

Buffer: 0.015M Potassium phosphate buffer, 0.15M Sodium chloride, pH 7.2. Preservative: 0.1% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

products categories :

Monoclonal Antibodies to Lipoproteins

ncbi gi num :

296635

ncbi acc num :

CAA25519.1

uniprot acc num :

P02647

ncbi mol weight :

30,778 Da

ncbi pathways :

ABC-family Proteins Mediated Transport Pathway (106573); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Amyloids Pathway (366238); Chylomicron-mediated Lipid Transport Pathway (106157); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Folate Metabolism Pathway (198833)

ncbi summary :

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq]

uniprot summary :

APOA1: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. Belongs to the apolipoprotein A1/A4/E family. Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Vesicle; Cell development/differentiation; Lipid-binding; Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 11q23-q24. Cellular Component: extracellular space; chylomicron; cell surface; endocytic vesicle; endoplasmic reticulum lumen; early endosome; plasma membrane; extracellular region; cytoplasmic vesicle; cytosol; nucleus; vesicle. Molecular Function: identical protein binding; protein binding; enzyme binding; phospholipid transporter activity; lipase inhibitor activity; beta-amyloid binding; cholesterol transporter activity; chemorepellent activity; cholesterol binding; phospholipid binding; phosphatidylcholine binding; high-density lipoprotein binding; apolipoprotein A-I receptor binding; apolipoprotein receptor binding. Biological Process: phototransduction, visible light; negative chemotaxis; negative regulation of lipase activity; axon regeneration in the peripheral nervous system; negative regulation of interleukin-1 beta secretion; sequestering of lipid; regulation of cholesterol absorption; transforming growth factor beta receptor signaling pathway; positive regulation of stress fiber formation; response to drug; platelet activation; cholesterol metabolic process; organ regeneration; regulation of Cdc42 protein signal transduction; adrenal gland development; positive regulation of hydrolase activity; positive regulation of Rho protein signal transduction; lipoprotein metabolic process; positive regulation of transferase activity; vitamin transport; cholesterol biosynthetic process; negative regulation of cytokine secretion during immune response; cholesterol homeostasis; response to estrogen stimulus; lipoprotein biosynthetic process; peptidyl-methionine modification; phosphatidylcholine biosynthetic process; positive regulation of lipoprotein lipase activity; blood vessel endothelial cell migration; cellular lipid metabolic process; platelet degranulation; phospholipid efflux; retinoid metabolic process; transmembrane transport; response to nutrient; phospholipid homeostasis; integrin-mediated signaling pathway; receptor-mediated endocytosis; positive regulation of fatty acid biosynthetic process; regulation of protein amino acid phosphorylation; cholesterol transport; negative regulation of heterotypic cell-cell adhesion; protein stabilization; protein amino acid oxidation; neurite regeneration; cholesterol efflux; G-protein coupled receptor protein signaling pathway; glucocorticoid metabolic process; reverse cholesterol transport; negative regulation of inflammatory response; endothelial cell proliferation; blood coagulation. Disease: Hypoalphalipoproteinemia, Primary; Amyloidosis, Familial Visceral

size1 :

1 mg

price1 :

370 USD

more info or order :

MyBioSource product webpage