MAb to Beta 2 Microglobulin | MyBioSource MBS310926 product information

product summary

request information :

company name :

MyBioSource

product type :

antibody

product name :

MAb to Beta 2 Microglobulin

catalog :

MBS310926

quantity :

0.2 mg

price :

515 USD

clonality :

monoclonal

host :

mouse

reactivity :

human

application :

immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS310926

products type :

Antibody

products full name :

MAb to Beta 2 Microglobulin

products short name :

Beta 2 Microglobulin

products name syn :

MAb to Beta 2-Microglobulin; Monoclonal Antibody to Beta 2-Microglobulin

other names :

beta-2-microglobulin; Beta-2-microglobulin; beta-2-microglobulin; OTTHUMP00000161912; beta-2-microglobin; beta chain of MHC class I molecules; beta-2-microglobulin; N/A

other gene names :

B2M; B2M; B2M; N/A

uniprot entry name :

B2MG_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

B1G6

host :

Mouse. Hybridization of NS1/Ag4.1 myeloma cells with spleen cells from Balb/c mice.

sequence length :

119

specificity :

Beta 2 Microglobulin. Specific for human Beta 2-microglobulin (MW 12kDa). Does not react with Beta 2-microglobulin from other species. Recognizes the HLA-Beta 2-microglobulin complex, free or associated with the membrane. The exact epitope for the antib

form :

Purified, Lyophilized. Reconstitute with 1ml distilled water.

concentration :

0.2mg/ml (prior to lyophilization)

storage stability :

Store lyophilized product at 2 to 8 degree C. After reconstitution, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles. The addition of 0.1% (w/v) sodium azide is recommended for storage of the reconstituted form for up to one month at 2

tested application :

Immunohistochemistry - Formalin

app notes :

Purification of HLA antigens associated with Beta 2-microglobulin. Fluorescence microscopy or flow cytometry: 2ug/5x10^5 cells/test. Immunohistochemistry: Working dilution: 1:25 - 1:50 (suitable on frozen sections or cell smears). Each laboratory s

other info1 :

Immunogen: Purified human Beta 2-microglobulin. Affinity Constant: Not determined

other info2 :

Buffer: Lyophilized from PBS containing 1mg/ml BSA. Preservative: No. Lyophilized: Yes. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.

products categories :

Monoclonal Antibodies to Proteins and Bioactive Peptides

products references :

Liabeuf A., et al., (1981), "An antigenic determinant of human Beta 2-microglobulin masked by the association with HLA heavy chains at the cell surface: analysis using monoclonal antibodies", J. Immunol., 127; 1542-1548.

ncbi gi num :

179318

ncbi acc num :

AAA51811.1

uniprot acc num :

P61769

ncbi mol weight :

13,715 Da

ncbi pathways :

Adaptive Immunity Signaling Pathway 366160!!Amyloids Pathway 366238!!Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway 366163!!Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!Class I MHC Mediated Antigen Processing Presentation Pathway 366161!!Cytokine Signaling In Immune System Pathway 366171!!Downstream Signaling In Naive CD8+ T Cells Pathway 138018!!HIV Infection Pathway 105983!!Host Interactions Of HIV Factors Pathway 106010

ncbi summary :

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

uniprot summary :

Function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Subunit structure: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Ref.14. Subcellular location: Secreted. Note: Detected in serum and urine. Ref.16 Ref.17. Post-translational modification: Glycation of Ile-21 is observed in long-term hemodialysis patients. Involvement in disease: Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [. MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. Ref.33Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.25 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32. Sequence similarities: Belongs to the beta-2-microglobulin family.Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

size :

0.2 mg

price :

515 USD

more info or order :

MyBioSource product webpage