catalog number :
MBS310668
products full name :
MAb to Insulin Receptor
products short name :
Insulin Receptor
products name syn :
Monoclonal Antibody to Insulin Receptor
other names :
Insulin receptor; Insulin receptor; insulin receptor; IR; insulin receptor; N/A
other gene names :
INSR; HHF5; CD220; N/A
uniprot entry name :
INSR_HUMAN
specificity :
Insulin Receptor. Alpha subunit of human insulin receptor. 90% inhibition of insulin binding adipocytes. Shown to activate receptor Kinase in receptor kinase assay.
storage stability :
Store (up to 1 year) at -20 degree C to -70 degree C. Avoid multiple freeze/thaw cycles.
other info1 :
Immunogen: Purified Human alpha subunit of insulin receptor. Affinity Constant: Not determined
other info2 :
Buffer: PBS, pH 7.0. Preservative: No
products categories :
Monoclonal Antibodies to Hormones and Steroids
products references :
Soos, et al., (1986) Biochem J., 235: 199. Brindle, et al., (1990) Biochem J., 268: 615. Prigent, et al., (1990) J. Biol. Chem., 265: 9970
ncbi pathways :
Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Aldosterone-regulated Sodium Reabsorption Pathway 130626!!Aldosterone-regulated Sodium Reabsorption Pathway 130590!!Downstream Signaling Of Activated FGFR Pathway 160957!!IRS Activation Pathway 106425!!IRS-mediated Signalling Pathway 106426!!IRS-related Events Pathway 106424!!Insulin Pathway 138026!!Insulin Signaling Pathway 198845
ncbi summary :
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]