Recombinant Human ERCC1 Protein | MyBioSource MBS306513 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human ERCC1 Protein

catalog :

MBS306513

quantity :

0.01 mg

price :

425 USD

product information

catalog number :

MBS306513

products type :

Recombinant Protein

products full name :

Recombinant Human ERCC1 Protein

products short name :

ERCC1

other names :

DNA excision repair protein ERCC-1; DNA excision repair protein ERCC-1; DNA excision repair protein ERCC-1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); excision repair cross-complementation group 1

products gene name :

ERCC1

other gene names :

ERCC1; ERCC1; UV20; COFS4; RAD10

uniprot entry name :

ERCC1_HUMAN

sequence length :

297

storage stability :

Store at -20 degree to -80 degree C. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

other info1 :

Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 61kDa (including GST). Source: Recombinant protein encoding human full length ERCC1 expressed in E Coli.

other info2 :

Domain: full length

ncbi gi num :

119538

ncbi acc num :

AB069681

ncbi mol weight :

25,211 Da

ncbi pathways :

DNA Repair Pathway (105837); Dual Incision Reaction In GG-NER Pathway (105887); Dual Incision Reaction In TC-NER Pathway (105892); Fanconi Anemia Pathway (377262); Fanconi Anemia Pathway (377128); Formation Of Incision Complex In GG-NER Pathway (105886); Formation Of Transcription-coupled NER (TC-NER) Repair Complex Pathway (105891); Global Genomic NER (GG-NER) Pathway (105884); Nucleotide Excision Repair Pathway (105883); Nucleotide Excision Repair Pathway (83044)

ncbi summary :

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]

uniprot summary :

ERCC1: a structure-specific DNA repair endonuclease responsible for the 5 -incision during DNA excision repair. Belongs to the ERCC1/RAD10/SWI10 family. Heterodimer composed of ERCC1 and XPF/ERRC4. Defects in ERCC1 are the cause of cerebro-oculo-facio-skeletal syndrome type 4, a degenerative autosomal recessive disorder of prenatal onset affecting the brain, eye and spinal cord. After birth, it leads to brain atrophy, hypoplasia of the corpus callosum, hypotonia, cataracts, microcornea, optic atrophy, progressive joint contractures and growth failure. Facial dysmorphism is a constant feature. Abnormalities of the skull, eyes, limbs, heart and kidney also occur. Low levels of this protein are associated with increased sensitivity to cisplatin. The overall survival of non-small cell lung cancer patients with single-nucleotide polymorphisms at codon 118 receiving platinum-based chemotherapy was significantly improved. Protein type: DNA repair, damage. Chromosomal Location of Human Ortholog: 19q13.32. Cellular Component: nucleoplasm; nucleotide-excision repair complex; transcription factor TFIID complex; nuclear chromosome, telomeric region; cytoplasm. Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; structure-specific DNA binding; single-stranded DNA specific endodeoxyribonuclease activity; TATA-binding protein binding; damaged DNA binding; single-stranded DNA binding. Biological Process: oogenesis; chromosome organization and biogenesis; DNA recombination; negative regulation of telomere maintenance; UV protection; post-embryonic hemopoiesis; transcription-coupled nucleotide-excision repair; double-strand break repair; nucleotide-excision repair, DNA damage removal; nucleotide-excision repair, DNA incision, 5 -to lesion; response to nutrient; response to X-ray; mitotic recombination; multicellular organism growth; male gonad development; isotype switching; pyrimidine dimer repair via nucleotide-excision repair; multicellular organismal aging; replicative cell aging; DNA repair; syncytium formation; DNA catabolic process, endonucleolytic; response to sucrose stimulus; nucleotide-excision repair, DNA incision, 3 -to lesion; cell proliferation; nucleotide-excision repair; embryonic organ development; spermatogenesis; response to oxidative stress. Disease: Cerebrooculofacioskeletal Syndrome 4

size1 :

0.01 mg

price1 :

425 USD