Recombinant Human C-MET Protein | MyBioSource MBS306512 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human C-MET Protein

catalog :

MBS306512

quantity :

0.01 mg

price :

425 USD

product information

catalog number :

MBS306512

products type :

Recombinant Protein

products full name :

Recombinant Human C-MET Protein

products short name :

C-Met

other names :

Hepatocyte growth factor receptor; Hepatocyte growth factor receptor; hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; met proto-oncogene tyrosine kinase; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; MET proto-oncogene, receptor tyrosine kinase; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met

products gene name :

C-Met

other gene names :

MET; MET; HGFR; AUTS9; RCCP2; c-Met; HGF receptor; SF receptor

uniprot entry name :

MET_HUMAN

sequence length :

1390

storage stability :

Store at -20 degree to -80 degree C. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

other info1 :

Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 50kDa (including GST). Source: Recombinant protein encoding human c-met aa 18-217 expressed in E Coli.

other info2 :

Domain: aa 18-217

ncbi gi num :

251757497

ncbi acc num :

P08581.4

ncbi gb acc num :

NM_000245

ncbi mol weight :

85,745 Da

ncbi pathways :

Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Alpha6-Beta4 Integrin Signaling Pathway (198807); Arf6 Signaling Events Pathway (138034); Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); Central Carbon Metabolism In Cancer Pathway (1059538)

ncbi summary :

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

Met: a proto-oncogenic receptor tyrosine kinase with high affinity for hepatocyte growth factor. The primary single chain precursor protein is post-translationally cleaved to produce the 45 kDa alpha- and 145 kDa beta-subunits, which are disulfide linked to form the mature receptor. Ligand-binding induces autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. Activating point mutations cause hereditary papillary renal carcinoma. Mutations also seen in sporadic renal cell carcinoma and childhood hepatocellular carcinoma. Upregulation in carcinomas and sarcomas correlates with metastasis and poor outcome. Some gastric carcinomas harbor a translocation that creates an activated TPR-Met fusion protein. A small molecule inhibitor (PHA-665752) shows an effect in gastric carcinoma xenografts. Inhibitors: SU11274, PHA-665752, mAbs. Two alternatively spliced human isoforms have been reported. Protein type: Membrane protein, integral; EC 2.7.10.1; Oncoprotein; Protein kinase, tyrosine (receptor); Kinase, protein; Protein kinase, TK; TK group; Met family. Chromosomal Location of Human Ortholog: 7q31. Cellular Component: cell surface; integral to plasma membrane; basal plasma membrane; plasma membrane; integral to membrane; extracellular region. Molecular Function: protein binding; protein-tyrosine kinase activity; hepatocyte growth factor receptor activity; protein phosphatase binding; ATP binding. Biological Process: axon guidance; skeletal muscle development; peptidyl-tyrosine phosphorylation; activation of MAPK activity; myoblast proliferation; protein amino acid autophosphorylation; myotube differentiation; muscle cell migration; hepatocyte growth factor receptor signaling pathway; signal transduction; glucose homeostasis; liver development; cell proliferation; cell surface receptor linked signal transduction; positive chemotaxis; branching morphogenesis of a tube; adult behavior; positive regulation of transcription from RNA polymerase II promoter; endothelial cell morphogenesis; brain development; placenta development. Disease: Hepatocellular Carcinoma; Renal Cell Carcinoma, Papillary, 1

size1 :

0.01 mg

price1 :

425 USD