catalog number :
MBS306412
products type :
Recombinant Protein
products full name :
Recombinant Human TGF beta 1 Protein
products short name :
TGF beta1
other names :
transforming growth factor beta-1; Transforming growth factor beta-1; transforming growth factor beta-1; TGF-beta-1; latency-associated peptide; prepro-transforming growth factor beta-1; transforming growth factor, beta 1; N/A
products gene name :
TGF beta1
other gene names :
TGFB1; TGFB1; CED; LAP; DPD1; TGFB; TGFbeta; TGFB; TGF-beta-1; LAP
uniprot entry name :
TGFB1_HUMAN
storage stability :
Store at -20 degree to -80 degree C. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
other info1 :
Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 35kDa (including GST). Source: Recombinant protein encoding human TGF beta 1 aa 309-391 expressed in E Coli.
other info2 :
Domain: aa 309-391
ncbi acc num :
NP_000651.3
ncbi gb acc num :
NM_000660.5
ncbi mol weight :
44,341 Da
ncbi pathways :
ACE Inhibitor Pathway 198763!!ALK1 Signaling Events Pathway 137968!!Adipogenesis Pathway 198832!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Cardiac Progenitor Differentiation Pathway 712094!!Cell Cycle Pathway 198811!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Chagas Disease (American Trypanosomiasis) Pathway 147809
ncbi summary :
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]