catalog number :
MBS306075
products type :
Recombinant Protein
products full name :
Recombinant Human IGF-1R Protein
products short name :
IGF-1R
other names :
insulin-like growth factor 1 receptor isoform 1; Insulin-like growth factor 1 receptor; insulin-like growth factor 1 receptor; IGF-I receptor; insulin-like growth factor I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD_antigen: CD221Cleaved into the following 2 chains:Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain
products gene name :
IGF-1R
other gene names :
IGF1R; IGF1R; IGFR; CD221; IGFIR; JTK13; IGF-I receptor
uniprot entry name :
IGF1R_HUMAN
storage stability :
Store at -20 degree to -80 degree C. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
other info1 :
Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 43kDa. Source: Recombinant IGF-1R protein encoding aa 1213-1367 expressed in E Coli.
other info2 :
Domain: aa 1213-1367
ncbi acc num :
NP_000866.1
ncbi gb acc num :
NM_000875
ncbi mol weight :
154,793 Da
ncbi pathways :
AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Apoptosis Pathway 198797!!Endochondral Ossification Pathway 198812!!Endocytosis Pathway 102279!!Endocytosis Pathway 102181!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067
ncbi summary :
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]