catalog number :
MBS306063
products type :
Recombinant Protein
products full name :
Recombinant Human gp100 (Melanoma) Protein
products short name :
gp100
other names :
gp100; Melanocyte protein PMEL; ME20-M; ME20M; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; P1; P100; Premelanosome protein; Silver locus protein homologCleaved into the following 2 chains:M-alphaAlternative name(s):95 kDa melanocyte-specific secreted glycoprotein; P26; Secreted melanoma-associated ME20 antigen; ME20-S; ME20S
products gene name :
gp100
other gene names :
PMEL; D12S53E; PMEL17; SILV; ME20M; ME20-S; ME20S
uniprot entry name :
PMEL_HUMAN
storage stability :
Store at -20 degree to -80 degree C. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
other info1 :
Characterization: gp100 antibody reactive; MW 96kDa. Source: Recombinant human gp100 protein encoding aa 1-640 expressed in E Coli.
other info2 :
Domain: aa 1-640
ncbi acc num :
AAC60634.1
ncbi mol weight :
66,729 Da
uniprot summary :
SILV: Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. Belongs to the PMEL/NMB family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Vesicle. Chromosomal Location of Human Ortholog: 12q13-q14. Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; melanosome; extracellular region; plasma membrane; integral to membrane. Molecular Function: protein binding. Biological Process: melanin biosynthetic process; melanosome organization and biogenesis