catalog number :
MBS306057
products type :
Recombinant Protein
products full name :
Recombinant Human S100A4 Protein
products short name :
S100A4
other names :
protein S100-A4; Protein S100-A4; protein S100-A4; S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog); fibroblast-specific protein-1; leukemia multidrug resistance associated protein; malignant transformation suppression 1; placental calcium-binding protein; protein Mts1; S100 calcium binding protein A4; Calvasculin; Metastasin; Placental calcium-binding protein; Protein Mts1; S100 calcium-binding protein A4
products gene name :
S100A4
other gene names :
S100A4; S100A4; 42A; 18A2; CAPL; FSP1; MTS1; P9KA; PEL98; CAPL; MTS1
uniprot entry name :
S10A4_HUMAN
form :
100ul purified humans S100A4 protein at 100ug/ml in 50mM Tris-HCl (pH.7.5) with 10mM L-glutathione (reduced)
storage stability :
Store at -20 degree to -80 degree C. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
other info1 :
Volume: 100ul. Characterization: S100A4 antibody reactive. Source: Recombinant full length human S100A4 protein expressed in E Coli.
other info2 :
Domain: full length. Warnings & Precautions: 1. Take reasonable precautions when handling reagents. Wear appropriate Personal Protective Equipment. 2. Avoid contact of reagents with eyes, mucous membranes and skin. If reagents come into contact with sensitive areas, wash with copious amounts of water. 3. Consult local or state authorities with regard to recommended method of disposal. 4. Avoid microbial contamination of reagents.
products description :
S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes.
ncbi acc num :
NP_062427.1
ncbi gb acc num :
NM_019554.2
ncbi summary :
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
uniprot summary :
S100A4: is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]. Protein type: Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: extracellular space; neuron projection; perinuclear region of cytoplasm; nucleus. Molecular Function: identical protein binding; RAGE receptor binding; protein binding; calcium ion binding; actin binding; calcium-dependent protein binding. Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; epithelial to mesenchymal transition