This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
protein
product name :
Recombinant Human PTEN Protein
catalog :
MBS306047
quantity :
0.01 mg
price :
420 USD
product information
catalog number :
MBS306047
products type :
Recombinant Protein
products full name :
Recombinant Human PTEN Protein
products short name :
PTEN
other names :
PTEN; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; mitochondrial PTENalpha; mitochondrial phosphatase and tensin protein alpha; mutated in multiple advanced cancers 1; phosphatase and tensin-like protein; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatase and tensin homolog; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog
products gene name :
PTEN
other gene names :
PTEN; PTEN; BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; MMAC1; TEP1
uniprot entry name :
PTEN_HUMAN
sequence length :
403
storage stability :
Store at -20 degree to -80 degree C. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
other info1 :
Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 86kDa. Source: Recombinant full length human PTEN protein expressed in E Coli.
other info2 :
Domain: full length
ncbi gi num :
4240387
ncbi acc num :
AAD13528.1
ncbi mol weight :
19,796 Da
ncbi pathways :
3-phosphoinositide Degradation Pathway 545349!!3-phosphoinositide Degradation Pathway 139488!!Adaptive Immune System Pathway 366160!!Androgen Receptor Signaling Pathway 198806!!BCR Signaling Pathway 138058!!Central Carbon Metabolism In Cancer Pathway 1059538!!Central Carbon Metabolism In Cancer Pathway 1084231!!Class I PI3K Signaling Events Pathway 138022!!Constitutive PI3K/AKT Signaling In Cancer Pathway 685535!!D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway 545328
ncbi summary :
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
size :
0.01 mg
price :
420 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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