catalog number :
MBS306001
products type :
Recombinant Protein
products full name :
Recombinant Human ALK/p80 Protein
products short name :
ALK/p80
other names :
ALK tyrosine kinase receptor; ALK tyrosine kinase receptor; ALK tyrosine kinase receptor; CD246 antigen; mutant anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; Anaplastic lymphoma kinase; CD_antigen: CD246
products gene name :
ALK/p80
other gene names :
ALK; ALK; CD246; NBLST3
uniprot entry name :
ALK_HUMAN
storage stability :
Store at -20 degree to -80 degree C. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
other info1 :
Source: Recombinant ALK/p80 protein encoding 426-528aa expressed in E Coli.
other info2 :
Domain: aa 426-528
ncbi acc num :
NP_004295.2
ncbi gb acc num :
NM_004304.4
ncbi mol weight :
176,442 Da
ncbi pathways :
Non-small Cell Lung Cancer Pathway 83119!!Non-small Cell Lung Cancer Pathway 531
ncbi summary :
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]