Rabbit Anti-Human VEGF Monoclonal Antibody (Clone SP28) | MyBioSource MBS302656 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Anti-Human VEGF Monoclonal Antibody (Clone SP28)

catalog :

MBS302656

quantity :

7 ml

price :

315 USD

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

SP28

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS302656

products type :

Antibody

products full name :

Rabbit Anti-Human VEGF Monoclonal Antibody (Clone SP28)

products short name :

Vascular Endothelial Growth Factor

other names :

vascular endothelial growth factor A isoform a; Vascular endothelial growth factor A; vascular endothelial growth factor A; vascular permeability factor; vascular endothelial growth factor A; Vascular permeability factor; VPF

products gene name :

VEGF

other gene names :

VEGFA; VEGFA; VPF; VEGF; MVCD1; VEGF; VEGF-A; VPF

uniprot entry name :

VEGFA_HUMAN

clonality :

Monoclonal

isotype :

IgG

clone :

SP28

host :

Rabbit

reactivity :

Human. Predicted Reactivity: Bovine, Pig

sequence length :

412

form :

7.0 ml pre-diluted rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

storage stability :

Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

tested application :

Immunohistochemistry (IHC) Paraffin

app notes :

Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: Ready-to-use Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: Ready To Use. IHC Positive Control: Angiosarcoma

other info2 :

Immunogen: Synthetic peptide derived from N-terminus of human VEGF. Control Tissue: Angiosarcoma. Cellular Localization: Cytoplasm, Extracellular Matrix, Membrane. Entrez Gene Code: 7422. Pathway: Angiogenesis

products description :

VEGF (vascular endothelial growth factor) is a homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. This antibody reacts with the 165, 189 and 121 amino acid splice variants of VEGF of human.

ncbi gi num :

76781480

ncbi acc num :

NP_001020537.2

ncbi gb acc num :

NM_001025366.2

ncbi mol weight :

19-28 kDa (Reduced)

ncbi pathways :

Angiogenesis Pathway 198772!!Axon Guidance Pathway 105688!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!Cellular Response To Hypoxia Pathway 645259!!Cellular Responses To Stress Pathway 645258!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Developmental Biology Pathway 477129!!EPH-Ephrin Signaling Pathway 1127691

ncbi summary :

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]

size :

7 ml

price :

315 USD