product summary
request information :
company name :
MyBioSource
product type :
antibody
product name :
Rabbit Anti-Human CD163 Monoclonal Antibody (Clone SP96)
catalog :
MBS302638
quantity :
0.1 ml
price :
265 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human
application :
immunohistochemistry - paraffin section, immunohistochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS302638
products type :
Antibody
products full name :
Rabbit Anti-Human CD163 Monoclonal Antibody (Clone SP96)
products short name :
CD163
other names :
scavenger receptor cysteine-rich type 1 protein M130 isoform a; Scavenger receptor cysteine-rich type 1 protein M130; scavenger receptor cysteine-rich type 1 protein M130; hemoglobin scavenger receptor; macrophage-associated antigen; CD163 molecule; Hemoglobin scavenger receptor; CD_antigen: CD163Soluble CD163; sCD163
products gene name :
CD163
other gene names :
CD163; CD163; M130; MM130; M130; sCD163
uniprot entry name :
C163A_HUMAN
clonality :
Monoclonal
isotype :
IgG
clone :
SP96
host :
Rabbit
reactivity :
Human. Predicted Reactivity: Bovine, Pig
sequence length :
1156
form :
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
storage stability :
Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
tested application :
Immunohistochemistry (IHC) Paraffin
app notes :
Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 1mM EDTA, pH 8.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: 1:100. IHC Positive Control: Lung
other info2 :
Immunogen: Synthetic peptide corresponding to near N-terminus of human CD163 protein. Control Tissue: Lung. Cellular Localization: Membrane. Entrez Gene Code: 9332. Pathway: Lymphocyte Signaling
products description :
CD163 is a 130kDa membrane glycoprotein. It is a member of the scavenger receptor cysteine-rich superfamily and is a receptor for the hemoglobin-haptoglobin complex. CD163 is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predominantly in the late phase of inflammation. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone. Lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) both induce shedding of CD163 from the cell surface into plasma or cell supernatant.
ncbi gi num :
344179110
ncbi acc num :
NP_004235.4
ncbi gb acc num :
NM_004244.5
ncbi mol weight :
130 kDa
ncbi pathways :
Binding And Uptake Of Ligands By Scavenger Receptors Pathway 771599!!Scavenging Of Heme From Plasma Pathway 771600
ncbi summary :
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
size :
0.1 ml
price :
265 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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