Rabbit Anti-Human Amyloid Precursor Protein (APP) Polyclonal Antibody | MyBioSource MBS302368 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Anti-Human Amyloid Precursor Protein (APP) Polyclonal Antibody

catalog :

MBS302368

quantity :

0.5 ml

price :

315 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS302368

products type :

Antibody

products full name :

Rabbit Anti-Human Amyloid Precursor Protein (APP) Polyclonal Antibody

products short name :

Amyloid Precursor Protein

other names :

amyloid beta A4 protein isoform a; Amyloid beta A4 protein; amyloid beta A4 protein; alzheimer disease amyloid protein; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); cerebral vascular amyloid peptide; peptidase nexin-II; preA4; protease nexin-II; amyloid beta (A4) precursor protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II

products gene name :

APP

other gene names :

APP; APP; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma; A4; AD1; APP; CVAP; PN-II; S-APP-alpha; S-APP-beta; AICD-59; AID(59); AICD-57; AID(57); AICD-50; AID(50)

uniprot entry name :

A4_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human. Predicted Reactivity: Dog, Mouse, Pig, Rat

sequence length :

770

form :

0.5 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

storage stability :

Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

tested application :

Immunohistochemistry (IHC) Paraffin

app notes :

Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: 1:100. IHC Positive Control: Alzheimer's Brain

other info2 :

Immunogen: Synthetic peptide corresponding to N-terminus of human APP. Control Tissue: Alzheimer's Brain. Cellular Localization: Cytoplasm, Extracellular Matrix. Entrez Gene Code: 351. Pathway: Neuroscience

products description :

This antibody recognizes APP (b-APP770), MW 110kDa. Predicted to recognize beta-APP695 and beta- APP751. Amyloid precursor protein (APP) and APP-like proteins are transmembrane glycoproteins with a similar modular domain structure.

ncbi gi num :

4502167

ncbi acc num :

NP_000475.1

ncbi gb acc num :

NM_000484.3

ncbi mol weight :

102 kDa

ncbi pathways :

Activated TLR4 Signalling Pathway 106400!!Advanced Glycosylation Endproduct Receptor Signaling Pathway 187092!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Amyloids Pathway 366238!!Caspase Cascade In Apoptosis Pathway 137974!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytosolic Sensors Of Pathogen-associated DNA Pathway 576255!!DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway 833822

ncbi summary :

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

size :

0.5 ml

price :

315 USD