Rabbit Anti-Human KOC/L523S Polyclonal Antibody | MyBioSource MBS301855 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Anti-Human KOC/L523S Polyclonal Antibody

catalog :

MBS301855

quantity :

7 ml

price :

285 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat, chicken

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS301855

products type :

Antibody

products full name :

Rabbit Anti-Human KOC/L523S Polyclonal Antibody

products short name :

KOC/L523S

other names :

insulin-like growth factor 2 mRNA-binding protein 3; Insulin-like growth factor 2 mRNA-binding protein 3; insulin-like growth factor 2 mRNA-binding protein 3; IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; KH domain containing protein overexpressed in cancer; VICKZ family member 3; cancer/testis antigen 98; insulin-like growth factor 2 mRNA binding protein 3; IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer; hKOC; VICKZ family member 3

products gene name :

KOC/L523S

other gene names :

IGF2BP3; IGF2BP3; KOC; CT98; IMP3; KOC1; IMP-3; VICKZ3; IMP3; KOC1; VICKZ3; IGF2 mRNA-binding protein 3; IMP-3; hKOC

uniprot entry name :

IF2B3_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human. Predicted Reactivity: Bovine, Chicken, Frog, Mouse, Rabbit, Rat

sequence length :

579

form :

0.5 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

storage stability :

Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

tested application :

Immunohistochemistry (IHC) Paraffin

app notes :

Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilutions: If using the concentrate format of this product, dilute the antibody 1:100 prior to use. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM Citrate buffer, pH 6.0 for 10-20 min followed by cooling at room temperature for 20 min. Primary Antibody: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: Ready To Use. IHC Positive Control: Prostate Carcinoma, Placenta

other info2 :

Immunogen: Synthetic peptide corresponding to internal region of human KOC/L523S. Control Tissue: Placenta, Prostate Carcinoma. Cellular Localization: Cytoplasm. Entrez Gene Code: 10643. Pathway: Translational Control

products description :

Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein over-expressed in cancer (KOC) and L523S, is a member of homology domain-containing protein over-expressed in cancer (KOC) and L523S, is a member of embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor.

ncbi gi num :

30795212

ncbi acc num :

NP_006538.2

ncbi gb acc num :

NM_006547.2

ncbi mol weight :

70 kDa

ncbi pathways :

Gene Expression Pathway 105937!!Insulin-like Growth Factor-2 MRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) Bind RNA Pathway 161026

ncbi summary :

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

size :

7 ml

price :

285 USD