product summary
request information :
company name :
MyBioSource
product type :
antibody
product name :
Rabbit Anti-Human Thioredoxin Reductase 2 (TRXR2) Polyclonal Antibody
catalog :
MBS301632
quantity :
0.1 ml
price :
165 USD
clonality :
polyclonal
host :
rabbit
reactivity :
mouse, rat, human
application :
immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS301632
products type :
Antibody
products full name :
Rabbit Anti-Human Thioredoxin Reductase 2 (TRXR2) Polyclonal Antibody
products short name :
Thioredoxin Reductase 2
other names :
thioredoxin reductase 2, mitochondrial isoform 1; Thioredoxin reductase 2, mitochondrial; thioredoxin reductase 2, mitochondrial; selenoprotein Z; thioredoxin reductase 3; thioredoxin reductase TR3; thioredoxin reductase beta; thioredoxin reductase 2; Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3
products gene name :
TrxR2
other gene names :
TXNRD2; TXNRD2; TR; TR3; SELZ; TRXR2; TR-BETA; KIAA1652; TRXR2; SelZ
uniprot entry name :
TRXR2_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human. Predicted Reactivity: Bovine, Frog, Mouse, Pig, Rabbit, Rat
sequence length :
524
form :
0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
storage stability :
Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
tested application :
Immunohistochemistry (IHC) Paraffin
app notes :
Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:50. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue sections in 10mM Citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: 1:50. IHC Positive Control: Liver Carcinoma
other info2 :
Immunogen: Synthetic peptide derived from C-terminus of human TrxR2. Control Tissue: Liver Carcinoma. Cellular Localization: Cytoplasm. Entrez Gene Code: 10587. Pathway: Signal Transduction
products description :
The reduced form of thioredoxin serves as a hydrogen donor, contributes to the up-regulation of various transcription factors and binds to and inhibits MAPKKK activity. Oxidized thioredoxin is converted back to the reduced form by Thioredoxin Reductase (TrxR2), a redox active enzyme. There are two distinct isoforms in mammalian cells, TrxR1, a cytosolic protein and TrxR2, almost exclusively a mitochondrial protein. TrxR expression is induced in several tumors.
ncbi gi num :
22035672
ncbi acc num :
NP_006431.2
ncbi gb acc num :
NM_006440.4
ncbi mol weight :
53 kDa
ncbi pathways :
Cellular Responses To Stress Pathway 645258!!Detoxification Of Reactive Oxygen Species Pathway 1127552!!Oxidative Stress Pathway 198916!!Pyrimidine Metabolism Pathway 82946!!Pyrimidine Metabolism Pathway 309!!Selenium Pathway 219762!!Selenium Pathway 198359!!Selenium Metabolism And Selenoproteins Pathway 198846!!Selenium Pathway 198825!!Selenocompound Metabolism Pathway 82969
ncbi summary :
This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]
size :
0.1 ml
price :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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