product summary
request information :
company name :
MyBioSource
product type :
antibody
product name :
Rabbit Anti-Human Prostate Apoptosis Response 4 (PAR-4) Polyclonal Antibody
catalog :
MBS301530
quantity :
0.1 ml
price :
165 USD
clonality :
polyclonal
host :
rabbit
reactivity :
human, rat
application :
immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS301530
products type :
Antibody
products full name :
Rabbit Anti-Human Prostate Apoptosis Response 4 (PAR-4) Polyclonal Antibody
products short name :
Prostate Apoptosis Response 4
other names :
PRKC apoptosis WT1 regulator protein; PRKC apoptosis WT1 regulator protein; PRKC apoptosis WT1 regulator protein; WT1-interacting protein; prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4; transcriptional repressor PAR4; PRKC, apoptosis, WT1, regulator; Prostate apoptosis response 4 protein; Par-4
products gene name :
PAR-4
other gene names :
PAWR; PAWR; PAR4; Par-4; PAR4; Par-4
uniprot entry name :
PAWR_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human. Predicted Reactivity: Mouse, Rat
sequence length :
340
form :
0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
storage stability :
Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
tested application :
Immunohistochemistry (IHC) Paraffin
app notes :
Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: 1:100. IHC Positive Control: Heart
other info2 :
Immunogen: Synthetic peptide derived from C-terminus of human prostate apoptosis response 4 protein. Control Tissue: Heart. Cellular Localization: Cytoplasm. Entrez Gene Code: 5074. Pathway: Apoptosis
products description :
Prostate apoptosis response-4 (Par-4) is a 38kDa protein originally identified as the product of a gene that is up-regulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain-containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par-4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration.
ncbi gi num :
55769533
ncbi acc num :
NP_002574.2
ncbi gb acc num :
NM_002583.2
ncbi mol weight :
116 kDa
ncbi pathways :
Ceramide Signaling Pathway 138023!!Coregulation Of Androgen Receptor Activity Pathway 138085!!IL-4 Signaling Pathway 198760
ncbi summary :
The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008]
size :
0.1 ml
price :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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