product summary
request information :
company name :
MyBioSource
product type :
antibody
product name :
Rabbit Anti-Human PDGFR-beta? Receptor Polyclonal Antibody
catalog :
MBS301500
quantity :
0.1 ml
price :
165 USD
clonality :
polyclonal
host :
rabbit
reactivity :
dog, human, rat, mouse
application :
immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS301500
products type :
Antibody
products full name :
Rabbit Anti-Human PDGFR-beta? Receptor Polyclonal Antibody
products short name :
PDGFR beta
other names :
platelet-derived growth factor receptor beta; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta; CD140 antigen-like family member B; PDGF-R-beta; PDGFR-beta; beta-type platelet-derived growth factor receptor; platelet-derived growth factor receptor 1; platelet-derived growth factor receptor, beta polypeptide; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD_antigen: CD140b
products gene name :
PDGFR beta
other gene names :
PDGFRB; PDGFRB; IMF1; IBGC4; JTK12; PDGFR; CD140B; PDGFR1; PDGFR-1; PDGFR; PDGFR1; PDGF-R-beta; PDGFR-beta; PDGFR-1
uniprot entry name :
PGFRB_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human. Predicted Reactivity: Chicken, Dog, Frog, Mouse, Pig, Rabbit, Rat
sequence length :
1106
form :
0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
storage stability :
Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
tested application :
Immunohistochemistry (IHC) Paraffin
app notes :
Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:50. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: 1:50. IHC Positive Control: Prostate, Skin, Ovarian Carcinoma
other info2 :
Immunogen: Synthetic peptide derived from C-terminus of human PDGFR beta. Control Tissue: Kidney, Ovarian Carcinoma, Skin. Cellular Localization: Cytoplasm, Membrane. Entrez Gene Code: 5159. Pathway: Signal Transduction
products description :
PDGFR (Platelet Derived Growth Factor Receptor) exhibits two different isoforms, alpha and beta coded by two different genes. PDGF-alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF-beta receptors are expressed on neurons. This antibody is specific for PDGFR beta and does not react with PDGFR alpha.
ncbi gi num :
4505683
ncbi acc num :
NP_002600.1
ncbi gb acc num :
NM_002609.3
ncbi mol weight :
190 kDa
ncbi pathways :
Adaptive Immune System Pathway 366160!!Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!Central Carbon Metabolism In Cancer Pathway 1059538!!Central Carbon Metabolism In Cancer Pathway 1084231!!Choline Metabolism In Cancer Pathway 1059539!!Choline Metabolism In Cancer Pathway 1084232!!Constitutive PI3K/AKT Signaling In Cancer Pathway 685535!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460
ncbi summary :
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]
size :
0.1 ml
price :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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