product summary
request information :
company name :
MyBioSource
product type :
antibody
product name :
Rabbit Anti-Human GluR1 Polyclonal Antibody
catalog :
MBS301279
quantity :
0.1 ml
price :
165 USD
clonality :
polyclonal
host :
rabbit
reactivity :
rat, human, mouse
application :
immunohistochemistry - paraffin section, immunohistochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS301279
products type :
Antibody
products full name :
Rabbit Anti-Human GluR1 Polyclonal Antibody
products short name :
GluR1
other names :
Metabotropic glutamate receptor 1; metabotropic glutamate receptor 1; protein phosphatase 1, regulatory subunit 85; glutamate receptor, metabotropic 1; N/A
products gene name :
GluR1
other gene names :
GRM1; GRM1; MGLU1; GPRC1A; MGLUR1; SCAR13; PPP1R85; GPRC1A; MGLUR1; mGluR1
uniprot entry name :
GRM1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human. Predicted Reactivity: Chicken, Mouse, Rat
sequence length :
908
form :
0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
storage stability :
Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
tested application :
Immunohistochemistry (IHC) Paraffin
app notes :
Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:50. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue sections in 10mM Citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: 1:50. IHC Positive Control: Brain
other info2 :
Immunogen: Synthetic peptide from C-terminus of human GluR1. Control Tissue: Brain. Cellular Localization: Cytoplasm. Entrez Gene Code: 2911. Pathway: Neuroscience
products description :
Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1-3, KAI-2), which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled receptors, which when activated can activate phopholipases or adenylylcyclase, depending on the neuron.
ncbi gi num :
166999098
ncbi acc num :
NP_000829.2
ncbi gb acc num :
NM_000838.3
ncbi mol weight :
110 kDa
ncbi pathways :
Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway 106381!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Disease Pathway 530764!!Estrogen Signaling Pathway 799177!!Estrogen Signaling Pathway 799197!!FoxO Signaling Pathway 921162!!G Alpha (q) Signalling Events Pathway 106043!!GPCR Downstream Signaling Pathway 119548
ncbi summary :
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
size :
0.1 ml
price :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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