catalog number :
MBS301102
products full name :
Rabbit Anti-Human CD68 Polyclonal Antibody
products short name :
CD68
other names :
macrosialin isoform B; Macrosialin; macrosialin; CD68 antigen; macrophage antigen CD68; scavenger receptor class D, member 1; CD68 molecule; Gp110; CD_antigen: CD68
products gene name :
CD68
other gene names :
CD68; CD68; GP110; LAMP4; SCARD1
uniprot entry name :
CD68_HUMAN
form :
0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
storage stability :
Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
tested application :
Western Blot (WB)
app notes :
Western Blot . Recommended Starting Protocol: Dilute the antibody 1:25. Incubate for 1 hour at room temperature. The dilution is an estimate; actual results may differ because of variability in methods and protocols. Optimal dilution and procedure should be determined by the end user. Western Blot Positive Control: Brain
other info2 :
Immunogen: Recombinant protein encoding aa 155-355 of human CD68. Cellular Localization: Membrane. Entrez Gene Code: 968. Pathway: Hematopoiesis
products description :
CD68 is an intracellular glycoprotein expressed on macrophages and monocytes. CD68 expression has been demonstrated in T cells, NK cells, liver and renal tubules.
ncbi acc num :
NP_001035148.1
ncbi gb acc num :
NM_001040059.1
ncbi pathways :
Lysosome Pathway 99052!!Lysosome Pathway 96865
ncbi summary :
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]