Rabbit Anti-Human TIMP-2 Polyclonal Antibody | MyBioSource MBS300709 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Anti-Human TIMP-2 Polyclonal Antibody

catalog :

MBS300709

quantity :

1 ml

price :

410 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat, dog, chicken

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS300709

products type :

Antibody

products full name :

Rabbit Anti-Human TIMP-2 Polyclonal Antibody

products short name :

TIMP-2

other names :

metalloproteinase inhibitor 2; Metalloproteinase inhibitor 2; metalloproteinase inhibitor 2; tissue inhibitor of metalloproteinases 2; TIMP metallopeptidase inhibitor 2; CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2

products gene name :

TIMP-2

other gene names :

TIMP2; TIMP2; DDC8; CSC-21K; TIMP-2

uniprot entry name :

TIMP2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human. Predicted Reactivity: Bovine, Chicken, Dog, Frog, Hamster, Mouse, Pig, Rabbit, Rat

sequence length :

220

form :

1.0 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

storage stability :

Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

tested application :

Immunohistochemistry (IHC) Paraffin

app notes :

Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:50. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM Citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at RT. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: 1:50. IHC Positive Control: Colon Carcinoma

other info2 :

Immunogen: Synthetic peptide derived from N-terminus half of human TIMP-2. Control Tissue: Colon Carcinoma. Cellular Localization: Cytoplasm. Entrez Gene Code: 7077. Pathway: Proteases and Protease Regulators

products description :

TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

ncbi gi num :

4507511

ncbi acc num :

NP_003246.1

ncbi gb acc num :

NM_003255.4

ncbi mol weight :

21 kDa

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway 576264!!Angiogenesis Pathway 198772!!Degradation Of The Extracellular Matrix Pathway 576263!!Extracellular Matrix Organization Pathway 576262!!Matrix Metalloproteinases Pathway 198900

ncbi summary :

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

size :

1 ml

price :

410 USD