MyBioSource

antibody

Rabbit Anti-Human FLT-4 Polyclonal Antibody

MBS300650

1 ml

410 USD

polyclonal

rabbit

human, rat

immunohistochemistry, immunohistochemistry - paraffin section

MBS300650

Antibody

Rabbit Anti-Human FLT-4 Polyclonal Antibody

FLT-4/VEGFR3

vascular endothelial growth factor receptor 3 isoform 2; Vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor 3; FLT-4; VEGFR-3; fms-like tyrosine kinase 4; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; tyrosine-protein kinase receptor FLT4; fms-related tyrosine kinase 4; Fms-like tyrosine kinase 4; FLT-4; Tyrosine-protein kinase receptor FLT4

FLT-4/VEGFR3

FLT4; FLT4; PCL; FLT41; LMPH1A; VEGFR3; VEGFR3; VEGFR-3; FLT-4

VGFR3_HUMAN

Polyclonal

IgG

Rabbit

Human. Predicted Reactivity: Dog, Pig, Rat

1298

1.0 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

Immunohistochemistry (IHC) Paraffin

Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue sections in 10mM Citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: 1:100. IHC Positive Control: Placenta, Breast Carcinoma

Immunogen: Synthetic peptide derived from C-terminus of human FLT-4 protein. Control Tissue: Breast Carcinoma, Placenta. Cellular Localization: Cytoplasm, Membrane. Entrez Gene Code: 2324. Pathway: Angiogenesis

Three cell membrane receptor tyrosine kinases, Flt (also designated VEGF-R1), Flk-1 (also designated VEGF-R2) and Flt-4 (also designated VEGF-R3), putatively involved in the growth of endothelial cells, are characterized by the presence of seven immuno-globulin-like sequences in their extracellular domain. On the basis of structural similarity to Flt and Flk-1, it has been speculated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand.

103472027

NP_002011.2

NM_002020.4

150 kDa

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478!!PI3K-Akt Signaling Pathway 692234!!PI3K-Akt Signaling Pathway 692979!!Rap1 Signaling Pathway 868086!!Rap1 Signaling Pathway 878042!!Ras Signaling Pathway 868085!!Signal Transduction Pathway 477114

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]

1 ml

410 USD