product summary
request information :
company name :
MyBioSource
product type :
antibody
product name :
Rabbit Anti-Human TIMP-3 Polyclonal Antibody
catalog :
MBS300646
quantity :
1 ml
price :
410 USD
clonality :
polyclonal
host :
rabbit
reactivity :
human, mouse, chicken, dog, rat
application :
immunohistochemistry - paraffin section, immunohistochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS300646
products type :
Antibody
products full name :
Rabbit Anti-Human TIMP-3 Polyclonal Antibody
products short name :
TIMP-3
other names :
metalloproteinase inhibitor 3; Metalloproteinase inhibitor 3; metalloproteinase inhibitor 3; MIG-5 protein; TIMP-3; protein MIG-5; tissue inhibitor of metalloproteinases 3; TIMP metallopeptidase inhibitor 3; Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3
products gene name :
TIMP-3
other gene names :
TIMP3; TIMP3; SFD; K222; K222TA2; HSMRK222; TIMP-3
uniprot entry name :
TIMP3_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human. Predicted Reactivity: Bovine, Chicken, Dog, Frog, Mouse, Rat
sequence length :
211
form :
1.0 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
storage stability :
Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
tested application :
Immunohistochemistry (IHC) Paraffin
app notes :
Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:70. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue sections in 10mM Citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: 1:70. IHC Positive Control: Placenta, Breast Carcinoma
other info2 :
Immunogen: Synthetic peptide derived from C-terminus of human TIMP-3. Control Tissue: Breast Carcinoma, Placenta. Cellular Localization: Cytoplasm. Entrez Gene Code: 7078. Pathway: Proteases and Protease Regulators
products description :
TIMPs (Tissue Inhibitors of Metallo Proteinases) form tight inhibitory complexes with MMPs which are involved in matrix degradation and hence, in tumor invasiveness and metastasis. TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
ncbi gi num :
4507513
ncbi acc num :
NP_000353.1
ncbi gb acc num :
NM_000362.4
ncbi mol weight :
23 kDa
ncbi pathways :
Angiogenesis Pathway 198772!!Endochondral Ossification Pathway 198812!!Matrix Metalloproteinases Pathway 198900!!MicroRNAs In Cancer Pathway 852705!!MicroRNAs In Cancer Pathway 852928!!Oncostatin M Signaling Pathway 711361!!Proteoglycans In Cancer Pathway 782000!!Proteoglycans In Cancer Pathway 782054
ncbi summary :
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]
size :
1 ml
price :
410 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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